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Top 10 Most Prescribed, Top-Selling Drugs

By Megan Brooks
Medscape Medical News

Aug. 5, 2014 -- There's been little change in the top-prescribed and top-selling prescription drugs in the United States, according to the latest data from research firm IMS Health.

Synthroid (levothyroxine) continues to be the nation's most-prescribed drug, and the antipsychotic Abilify (aripiprazole) continues to have the highest sales.

The data reflect a rolling 12 months of history (July 2013 - June 2014) on the top 100 drugs by total sales and total prescriptions in the U.S.

The top 10 drugs by number of monthly prescriptions are:  

  1. Synthroid, 22.6 million
  2. Crestor, 22.5 million
  3. Nexium, 18.6 million
  4. Ventolin HFA, 17.5 million
  5. Advair Diskus, 15.0 million
  6. Diovan, 11.4 million
  7. Lantus Solostar, 10.1 million
  8. Cymbalta, 10.0 million
  9. Vyvanse, 10.0 million
  10. Lyrica, 9.6 million

The top 10 drugs by sales are:

  1. Abilify, $7.2 billion
  2. Humira, $6.3 billion
  3. Nexium, $6.3 billion
  4. Crestor, $5.6 billion
  5. Enbrel, $5.0 billion
  6. Advair Diskus, $5.0 billion
  7. Sovaldi, $4.4 billion
  8. Remicade, $4.3 billion
  9. Lantus Solostar, $3.8 billion
  10. Neulasta, $3.6 billion

The complete list of the top 100 can be found on Medscape.

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