Oral HPV and Cancer

Scientists have known for decades about the link between the human papillomavirus (HPV) and cervical cancer. But only in the last few years have they learned that an oral infection with the virus can also cause cancers of the head and neck.

Most people who get oral HPV don’t get cancer. Your body usually fights the virus before you even know you have it. But head and neck cancers are on the rise, and scientists say oral HPV may be the cause.

The good news? You can take basic steps to prevent infection and protect yourself from cancer.

How Does Oral HPV Spread?

About 7% of Americans have oral HPV. That's far fewer than the number who have the genital version, which is the most common sexually transmitted disease in the U.S.

Scientists are still learning how oral HPV spreads. Only a few studies have looked into how people get infected. Many doctors suspect it’s passed on through oral sex, but no one can say for sure. It’s also uncertain if you can get the virus from deep "French" kissing. But it is clear that you can’t get oral HPV from casual contact, like kissing on the cheek or sharing a drink with an infected person.

You may never know you have HPV. The virus doesn’t cause symptoms, and most of the time, your immune system clears the infection from your body within 2 years. But in some cases, after many years, the virus can lead to cancer of the head or neck.

How Does Oral HPV Cause Head and Neck Cancer?

More than 40 types of HPV can infect people, but only a few cause cancer. One of the types that causes most cervical cancers, called HPV16, is also linked with most HPV-related head and neck cancers.

When HPV infects cells, it causes them to physically change. If your immune system can’t fight the infection, those changes can lead to tumors. They usually develop in the throat, near the tonsils, at the back of the roof of the mouth, or at base of the tongue.

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It takes a long time for the virus to make enough changes to cells to cause tumors. You can be infected for 10 years or more before a cancer develops.

The CDC estimates that roughly 8,400 Americans are diagnosed with HPV-related head and neck cancers each year. Men are three times more likely to get them than women. They're most common in people under age 60, especially those in their 30s and 40s.

Head and neck cancers are serious diseases, but doctors have found that HPV-related tumors respond very well to treatment.

Vaccines

Vaccines for women and men can prevent an infection from the HPV strains that cause cervical cancer. Can they also protect against an oral infection and head and neck cancer?

Possibly. Scientists made the available vaccines, Gardasil and Cervarix, to prevent cervical cancer. They haven’t yet tested them to see if they work against throat or other head and neck cancers. But since the vaccines work by preventing an HPV infection, many doctors think it’s likely they can prevent any kind of cancer caused by the strains of the virus that are included in the vaccine.

How to Lower Your Risk

Scientists need to do more research before they can recommend a surefire way to prevent oral HPV. But it’s always a good idea to practice safe sex. Condoms and dental dams can help prevent oral STDs.

It may also help to strengthen your body's immune system, so it can fight infections like oral HPV. Make these healthy habits part of your daily life, and tell your doctor if you need help getting started:

  • Eat a healthy diet rich in fruits, vegetables, and whole grains.
  • Exercise regularly.
  • Get plenty of sleep.
  • Don’t smoke.
WebMD Medical Reference Reviewed by Melinda Ratini, DO, MS on September 15, 2015

Sources

SOURCES:

CDC: “Human papillomavirus (HPV) and Oropharyngeal Cancer – Fact Sheet.

Johns Hopkins Medicine: “HPV and Head and Neck Cancer.”

Oral Cancer Foundation: “HPV/Oral Cancer Facts.”

Mount Sinai Hospital: “Human HPV and Throat/Oral Cancer, Frequently Asked Questions.”

Harvard Health: “How to boost your immune system.”

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