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New Drug Reverses Dentists' Anesthesia

FDA Approves OraVerse, the First Drug to Reverse Local Anesthesia Used During Dental Procedures
By
WebMD Health News
Reviewed by Louise Chang, MD

May 12, 2008 -- The FDA has approved OraVerse, the first drug indicated for reversing the effects of local anesthesia used by dentists.

According to Novalar Pharmaceuticals, the drug company that makes OraVerse, the FDA approved OraVerse's use in adults and children based on several clinical studies in which patients got an injection of OraVerse or a placebo after undergoing dental procedures under local anesthetics.

In the clinical studies, the patients who got OraVerse regained normal sensation in their lips faster than those who got the placebo. Within an hour after getting OraVerse, 41% of the patients had normal sensation in their lower lip, compared with 7% of those who got the placebo. And 59% of the OraVerse patients regained normal sensation in their upper lip within an hour after getting OraVerse, compared with 12% of those who got the placebo.

A Novalar news release states that no serious side effects were seen in the clinical studies; the most common side effect was pain at the injection site.

Novalar notes that although fast heart rate (tachycardia) and cardiac arrhythmia may occur when drugs like OraVerse are given intravenously, such problems are uncommon when OraVerse is injected into the gums.

OraVerse isn't recommended for use in children younger than 6 or children under 33 pounds.

 

How Do I Measure Up? Get the Facts Fast!

Number of Days Per Week I Floss

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Only 18.5% of Americans never floss. You are missing out on a simple way to make a big difference in the health of your mouth. Regardless of how well you brush, plaque still forms between your teeth and along your gums. Floss removes food trapped between the teeth and removes the film of bacteria that forms there before it turns to plaque, which can cause inflamed gums (gingivitis), cavities, and tooth loss. Try flossing just one tooth to get started.

You are one of 31% of Americans who don't floss daily. You are missing out on a simple way to make a big difference in the health of your mouth. Regardless of how well you brush, plaque still forms between your teeth and along your gums. Toothbrush bristles alone cannot clean effectively between these tight spaces. Flossing removes up to 80% of the film that hardens to plaque, which can cause inflamed gums (gingivitis), cavities, and tooth loss. Aim for 3 more days!

You are one of 31% of Americans who don't floss daily, but you're well on your way to making a positive impact on your teeth and gums. Regardless of how well you brush, plaque still forms between your teeth and along your gums. Toothbrush bristles alone cannot clean effectively between these tight spaces. Flossing removes up to 80% of the film that hardens to plaque, which can cause inflamed gums (gingivitis), cavities, and tooth loss. Aim for all 7 days!

Only 50.5% of Americans floss daily, and good for you that you are one of them! Regardless of how well you brush, plaque still forms between your teeth and along your gums. Toothbrush bristles alone cannot clean effectively between these tight spaces. Flossing removes up to 80% of the film that hardens to plaque, which can cause inflamed gums (gingivitis), cavities, and tooth loss. Congratulations on your good oral health habit!

SOURCES:

American Dental Association, Healthy People 2010

This tool is intended only for adults 18 and older.

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