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Indication
Synvisc-One® (hylan G-F 20) is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics, e.g., acetaminophen.

Important Safety Information for Synvisc-One
Before trying Synvisc-One, tell your doctor if you have had an allergic reaction, such as swelling of the face, tongue or throat, respiratory difficulty, rash, itching or hives to SYNVISC or any hyaluronan-based products.

View the complete prescribing information for Synvisc-One (PDF).

Is Osteoarthritis Knee Pain Sabotaging Your Exercise Routine?

Most osteoarthritis knee pain sufferers know that exercise is a crucial part of treatment. Unfortunately, many get caught in what's known as the vicious cycle of knee pain. Your knee hurts, so you start avoiding activities and exercise, which can lead to weight gain and more knee pain.

How do exercise and knee pain relief go hand in hand?

"If all the benefits of exercise could be put into a single pill, it would be the most widely prescribed medicine in the world," says Dr. Nicholas DiNubile, an orthopaedic surgeon specializing in sports medicine.

But it's hard to exercise when you're in pain. The sooner you find a treatment that relieves your osteoarthritis knee pain, the sooner you may get back to the exercises that benefit your knees most.

Which treatment can help relieve your osteoarthritis knee pain?

If you've tried exercise and over-the-counter pain relievers and haven't found enough knee pain relief, Synvisc-One® (hylan G-F 20) could help.

Synvisc-One is a different way to treat osteoarthritis knee pain. It's a viscosupplement injection made from a natural substance that lubricates and cushions the joint, and provides up to 6 months of knee pain relief with just 1 injection.

Ask your doctor about getting up to 6 months of osteoarthritis knee pain relief.

Synvisc-One can relieve osteoarthritis knee pain for up to 6 months with just 1 injection, providing knee pain relief.

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Important Safety Information for Synvisc-One

Before trying Synvisc-One, tell your doctor if you have had an allergic reaction, such as swelling of the face, tongue or throat, respiratory difficulty, rash, itching or hives to SYNVISC or any hyaluronan-based products. Should not be used in patients with an infected knee joint, skin disease or infection around the area where the injection will be given, or circulatory problems in the legs.

Synvisc-One is only for injection into the knee, performed by a doctor or other qualified health care professional. Synvisc-One has not been tested to show pain relief in joints other than the knee. Tell your doctor if you are allergic to products from birds – such as feathers, eggs or poultry – or if your leg is swollen or infected.

Synvisc-One has not been tested in children (≤21years old), pregnant women or women who are nursing. You should tell your doctor if you think you are pregnant or if you are nursing a child.

Talk to your doctor before resuming strenuous weight-bearing activities after treatment.

The side effects sometimes seen after Synvisc-One include (<2% each): pain, swelling, heat, redness, and/or fluid build-up in or around the knee. Tell your doctor if you experience any side effects after treatment with Synvisc One.

© 2013 Genzyme Corporation, a Sanofi Company.
All rights reserved. Synvisc-One, SYNVISC and GENZYME are registered trademarks of Genzyme Corporation.
US.SYN.13.04.022

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