Pomegranates May Fight Osteoarthritis
Pomegranate fruit extract may help save joints, study shows
WebMD News Archive
Sept. 9, 2005 -- Could osteoarthritis be brought to its knees by a simple
Researchers aren't making that declaration just yet. But they have found
signs that natural compounds called antioxidants in pomegranates may thwart
Osteoarthritis is the most common type of arthritis, with more than 20
million patients in the U.S., according to the National Institute of Arthritis
and Musculoskeletal and Skin Diseases (NIAMS).
The pomegranate study was done at Case Western Reserve University. The
researchers included Tariq Haqqi, PhD, a professor of medicine. The results
appear in The Journal of Nutrition.
Pomegranate extract was pitted against osteoarthritis in lab tests. That's
not the same as tests on people or animals, but it's a first step.
Pomegranate extract did two things in those lab tests. It cut levels of an
inflammatory chemical called interleukin-1b (IL-1b). It also curbed enzymes
that erode cartilage.
Cartilage is a hard but slippery coating on the end of each bone that helps
bones slide smoothly past each other. Osteoarthritis develops when cartilage is
broken down; exposed bone breaks down, causing pain, inflammation, and
This is the first study to show pomegranate's potential against
osteoarthritis, note the researchers.
The results "indicate the pomegranate fruit extract or compounds derived
from it may inhibit cartilage degradation in osteoarthritis and may also be a
useful nutritive supplement for maintaining joint integrity and function,"
"Arthritis is one of the foremost diseases for which patients seek
herbal or traditional medicine treatments," says Haqqi in a news
"However, all the extracts and herbs have not been scientifically
evaluated for their efficacy and safety. Indeed, some of them may even
interfere with current treatments," he continues.
"Therefore, careful use of supplements and herbal medicines during early
stages of disease or treatment may be made to limit the disease
progression," says Haqqi.
As always, discuss any supplement use with your doctor.
The researchers didn't just crack open a pomegranate and put it in a
blender. They also didn't use juice from the supermarket.
Instead, they made their own pomegranate extract from powdered pomegranate.
Sophisticated filtering and measuring was used for science's sake.
The pomegranate has "been revered through the ages for its medicinal
uses," write the researchers.
Antioxidants in pomegranates fight inflammation and may also counter cancer
and heart disease.
In May, researchers reported that pomegranate juice may help prevent the
return of prostate cancer. In March, another study showed that pomegranate
juice may fight hardening of the arteries.
Pomegranates are in season in the U.S. in the fall. They've got a thick,
red, leathery skin. The seeds inside are the edible part.
Want to try a pomegranate? You might want to wear a bib or old clothes. The
seeds leave a very strong stain and are used as a dye.