Calcium Supplements May Interfere With Thyroid Treatment
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These findings and others, Harshman says, show that it is critical for
thyroid patients to tell their physicians about all the medications they take.
Prior studies have shown that other widely used therapies, such as aluminum
hydroxide, found in various antacids; high-dose iron; and sucralfate, widely
prescribed for gastrointestinal disorders, have a negative impact on the
absorption of thyroxine.
Sherman, who conducted the sucralfate studies, agrees. He saw a "75 to
90%" rate of absorption problems in people taking thyroxine and sucralfate
at the same time. "Obviously, this induced significant hypothyroidism. But
because this is a drug that patients are prescribed, it is not likely a
clinician won't know about its use," Sherman says. "In the case of
aluminum hydroxide, high-dose iron, and now calcium, patients may not think to
tell their physicians they are taking them. Physicians need to ask their
patients about over-the-counter medications."
- Up to one-tenth of all Americans have some degree of thyroid
problems, and an underactive thyroid primarily affects postmenopausal women,
who also are at higher risk for osteoporosis.
- Many of these women take calcium supplements to protect against bone loss.
This can cause the medication known as thyroxine, which is widely prescribed to
treat an underactive thyroid, to have problems getting into the bloodstream.
This can cause thyroxine to be less effective.
- Patients can take these two drugs six to 12 hours apart, instead of
together, to prevent interference, and everyone should always inform their
doctor of all medications and supplements they are taking.