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Type 1 Diabetes Tied to Thinner Bones
Jan. 27, 2006 -- Women with type 1 diabetes may want to consider getting their bone density checked before menopause, researchers report.
The scientists studied bone density in women with and without type 1 diabetes. Their finding: Women with type 1 diabetes tended to have thinner bone and more bone fractures.
Thinner bone is at higher risk to break and can be a sign of developing osteoporosis, in which bone density dips dangerously low. Think of the difference between a thin, brittle twig and a thick, firm tree branch -- denser is better to avoid a sudden snap.
The University of Pittsburgh's Elsa Strotmeyer, PhD, and colleagues conducted the study, which appears in Diabetes Care.
Study Details
Osteoporosis usually strikes later in life. In women, it's typically seen after menopause. Men can also develop osteoporosis, but Strotmeyer's study only included women.
Participants were 67 women with type 1 diabetes and 237 women without diabetes. The women were 33-55 years old and had not gone through menopause.
The researchers checked the women's height, weight, and bone density. The women also completed surveys about health habits that can help bones (such as weight-bearing exercise) or hurt bones (such as smoking, heavy drinking, use of certain medications, and skimping on calcium and vitamin D).
Weaker Bones With Type 1 Diabetes
Even after adjusting for those factors, women with type 1 diabetes had lower bone density than those without diabetes.
In addition, a third of women with type 1 diabetes reported having a bone fracture after age 20, compared with less than a quarter of those without diabetes.
It's not known if the results apply to men or to people with type 2 diabetes, since they weren't included in the study.
Most people with diabetes have type 2 diabetes, which usually starts later in life than type 1 diabetes. For instance, in Strotmeyer's study, women with type 1 diabetes had been diagnosed at age 10, on average, and had had type 1 diabetes for more than 30 years.
Bone Density Tests
To measure the women's bone density, the researchers used a DEXA (dual-energy X-ray absorptiometry) machine. The machine checked the women's overall bone density as well as the density of their hips, neck, and spine.
Bone density peaks in the 30s. After that, bones gradually lose density over time. Bone density tests usually aren't done until after menopause, since that's when bone density starts to decline at a greater rate.
If the study's findings are correct, type 1 diabetes could join the list of other osteoporosis risk factors, which include:
- Being postmenopausal
- Having a family history of osteoporosis
- Being of European or Asian ancestry
- Having a medical condition such as hyperthyroidism that makes it hard to absorb enough calcium
- Having a small frame
- Being a smoker
Treating osteoporosis can mean taking prescription drugs, boosting intake of calcium, vitamin D, and other bone-friendly nutrients, and getting weight-bearing exercise. Walking, jogging, hiking, dancing, and lifting weights are some examples of weight-bearing exercise. Biking and swimming aren't in that group, since the bike or water carries your weight.
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VIVELLE-DOT (estradiol transdermal system) IS AVAILABLE BY PRESCRPTION ONLY.
INDICATION
Vivelle-Dot is used after menopause to: reduce moderate to severe hot flashes; treat moderate to severe dryness, itching and burning in or around the vagina; help reduce your chances of getting osteoporosis (thin weak bones); and treat certain conditions in which a young woman's ovaries do not produce enough estrogens naturally. Vivelle-Dot 0.025 mg/day is only used to prevent osteoporosis from menopause. If you use Vivelle-Dot only to treat your dryness, itching, and burning in and around your vagina or if you use Vivelle-Dot only to prevent osteoporosis from menopause, talk with your healthcare professional about whether a different treatment or medicine without estrogens might be better for you.
IMPORTANT SAFETY INFORMATION
Estrogens increase the chances of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are taking estrogens. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb).
Do not use estrogens with or without progestins to prevent heart disease, heart attacks, or strokes. Using estrogens with or without progestins may increase your chances of getting heart attacks, strokes, breast cancer, and blood clots. Using estrogens with progestins may increase your risk of dementia (decline in memory and thinking skills).
Vivelle-Dot should not be used if you have unusual vaginal bleeding; currently have or have had certain cancers, including cancer of the breast or uterus; had a stroke or heart attack in the recent past (for example, in the past year); currently have or have had blood clots; currently have or have had liver problems; or think you may be, or know that you are, pregnant.
The most common side effects that may occur with Vivelle-Dot are headache, breast tenderness, and back pain.
You and your healthcare professional should talk regularly about whether you still need treatment with Vivelle-Dot.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
Please see Full Prescribing Information for Vivelle-Dot.
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