March 24, 2010 -- Weird below-the-hip thigh fractures linked to Fosamax and
other osteoporosis drugs are rare -- but even if they tripled these injuries,
they'd still prevent more fractures than they caused.
These unusual bone fractures are nearly straight breaks across the thigh
bone well below the hip, caused by very slight falls. The odd fractures appear
to be more common in patients taking the osteoporosis drugs known as
bisphosphonates: Fosamax, Actonel, Boniva, and Reclast.
"We concluded that if you treat 1,000 women with osteoporosis for three
years, these drugs would prevent 100 fractures, including 11 hip fractures,"
Dennis M. Black, PhD, of the University of California, San Francisco, tells
WebMD. "And even if you posit a threefold increase in fracture risk from these
drugs, only one of those 1,000 women would have an upper thigh fracture."
Black and colleagues looked at patients enrolled in their placebo-controlled
clinical trial of Fosamax, including patients who took the drug in an extension
trial for 10 years. They also looked at data from their clinical trial of
Reclast. The trials were sponsored by the drugmakers Merck and Novartis.
Among the 14,195 women in these studies -- including some 1,100 women in the
long-term Fosamax trial -- there were only 12 of the unusual thigh fractures in
"These fractures do seem to occur and they are frightening, yet the evidence
so far suggests that relative to common hip fractures they are quite rare,"
Columbia University endocrinologist Elizabeth Shane, MD, tells WebMD. "The
concern doctors have is that people will forget about the many thousands of hip
fractures prevented by bisphosphonates and focus on the relatively rare
fractures that may or may not be caused by them."
Shane is co-chair of an international task force that has been investigating
the link between unusual fractures and bisphosphonates. Their report is
expected in two or three months.
Susan Bukata, MD, director of the Center for Bone Health at the University
of Rochester, N.Y., agrees.
"These are real, but they are incredibly rare relative to the number of
total hip fractures and the number of hip fractures saved on these drugs,"
Bukata tells WebMD via email.
Shane notes that the unusual fractures -- sometimes called hip fractures
because they occur below the hip, and sometimes called thigh fractures because
they involved the thigh bone (femur) -- make up only 2% to 4% of all hip
fractures. And only about at third of these fractures are linked to
"Bisphosphonates are important drugs for preventing typical hip fractures,
which are every bit as devastating as these unusual fractures," Shane says.
"While they are important and of great concern, we want to find out who is at
risk and tailor our therapy to reduce that risk as much as possible."