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    Ovarian Cancer Health Center

    Medical Reference Related to Ovarian Cancer

    1. Ovarian Cancer Prevention (PDQ®): Prevention - Patient Information [NCI] - Ovarian Cancer Prevention

      Avoiding risk factors and increasing protective factors may help prevent cancer.Avoiding cancer risk factors may help prevent certain cancers. Risk factors include smoking, being overweight, and not getting enough exercise. Increasing protective factors such as quitting smoking, eating a healthy diet, and exercising may also help prevent some cancers. Talk to your doctor or other health care professional about how you might lower your risk of cancer.The following risk factors may increase the risk of ovarian cancer:Family history of ovarian cancerA woman whose mother or sister had ovarian cancer has an increased risk of ovarian cancer. A woman with two or more relatives with ovarian cancer also has an increased risk of ovarian cancer. Inherited riskThe risk of ovarian cancer is increased in women who have inherited certain changes in the following genes:BRCA1 or BRCA2 genes.Genes that are linked to hereditary nonpolyposis colorectal cancer (HNPCC; Lynch syndrome).Hormone replacement

    2. Ovarian Cancer Screening (PDQ®): Screening - Patient Information [NCI] - Questions or Comments About This Summary

      If you have questions or comments about this summary, please send them to Cancer.gov through the Web site's Contact Form. We can respond only to email messages written in English.

    3. Ovarian Epithelial Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Options by Stage

      A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your doctor for clinical trials that are not listed here but may be right for you.Stage I and II Ovarian Epithelial CancerTreatment of stage I and stage II ovarian epithelial cancer may include the following:Hysterectomy, bilateral salpingo-oophorectomy, and omentectomy. Lymph nodes and other tissues in the pelvis and abdomen are removed and examined under the microscope to look for cancer cells.Unilateral salpingo-oophorectomy may be done in certain women who wish to have children.A clinical trial of internal or external radiation therapy.A clinical trial of chemotherapy.A clinical trial of surgery followed by chemotherapy or watchful waiting (closely monitoring a patient's condition without giving any treatment until symptoms appear or change).A clinical trial of a new treatment.Check for U.S. clinical trials from

    4. Ovarian Epithelial Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Options By Stage

      A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your doctor for clinical trials that are not listed here but may be right for you.Stage I Ovarian Germ Cell TumorsTreatment depends on whether the tumor is a dysgerminoma or another type of ovarian germ cell tumor. Treatment of dysgerminoma may include the following: Unilateral salpingo-oophorectomy with or without lymphangiography or CT scan.Unilateral salpingo-oophorectomy followed by observation.Unilateral salpingo-oophorectomy followed by radiation therapy.Unilateral salpingo-oophorectomy followed by chemotherapy.Treatment of other ovarian germ cell tumors may be either: unilateral salpingo-oophorectomy followed by careful observation; orunilateral salpingo-oophorectomy, sometimes followed by combination chemotherapy.Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting

    5. Ovarian Epithelial Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - Get More Information From NCI

      Call 1-800-4-CANCERFor more information, U.S. residents may call the National Cancer Institute's (NCI's) Cancer Information Service toll-free at 1-800-4-CANCER (1-800-422-6237) Monday through Friday from 8:00 a.m. to 8:00 p.m., Eastern Time. A trained Cancer Information Specialist is available to answer your questions.Chat online The NCI's LiveHelp® online chat service provides Internet users with the ability to chat online with an Information Specialist. The service is available from 8:00 a.m. to 11:00 p.m. Eastern time, Monday through Friday. Information Specialists can help Internet users find information on NCI Web sites and answer questions about cancer. Write to usFor more information from the NCI, please write to this address:NCI Public Inquiries Office9609 Medical Center Dr. Room 2E532 MSC 9760Bethesda, MD 20892-9760Search the NCI Web siteThe NCI Web site provides online access to information on cancer, clinical trials, and other Web sites and organizations that offer support

    6. Ovarian Cancer Screening (PDQ®): Screening - Patient Information [NCI] - Questions or Comments About This Summary

      If you have questions or comments about this summary, please send them to Cancer.gov through the Web site's Contact Form. We can respond only to email messages written in English.

    7. Ovarian Cancer Screening (PDQ®): Screening - Patient Information [NCI] - nci_ncicdr0000062829-nci-header

      This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER.Ovarian Epithelial Cancer Treatment

    8. Ovarian Cancer Prevention (PDQ®): Prevention - Patient Information [NCI] - Stage Information for Ovarian Germ Cell Tumors

      In the absence of obvious metastatic disease, accurate staging of germ cell tumors of the ovary requires laparotomy with careful examination of the following:Entire diaphragm.Both paracolic gutters.Pelvic nodes on the side of the ovarian tumor.The para-aortic lymph nodes.The omentum.The contralateral ovary should be carefully examined and biopsied if necessary. Ascitic fluid should be examined cytologically. If ascites is not present, it is important to obtain peritoneal washings before the tumor is manipulated. In patients with dysgerminoma, lymphangiography or computed tomography is indicated if the pelvic and para-aortic lymph nodes were not carefully examined at the time of surgery. Although not required for formal staging, it is desirable to obtain serum levels of alpha fetoprotein (AFP) and human chorionic gonadotropin (hCG) as soon as the diagnosis is established since persistence of these markers in the serum after surgery indicates unresected tumor.Definitions: FIGOThe

    9. Ovarian Cancer Screening (PDQ®): Screening - Patient Information [NCI] - Overview

      Note: Separate PDQ summaries on Ovarian Cancer Prevention; Ovarian Epithelial Cancer Treatment; Ovarian Germ Cell Tumor Treatment; and Ovarian Low Malignant Potential Tumor Treatment are also available. Evidence of Benefit or Lack of Benefit Associated with ScreeningSingle-threshold cancer antigen 125 (CA-125) levels and transvaginal ultrasound (TVU)There is solid evidence to indicate that routine screening for ovarian cancer with the serum marker CA-125 and TVU does not result in a decrease in mortality from ovarian cancer.Magnitude of Effect: No reduction in mortalityStudy Design: Evidence obtained from one randomized controlled trial.Internal Validity: Good.Consistency: One trial has evaluated the impact on mortality from ovarian cancer.External Validity: Good.Statement of HarmsBased on solid evidence, routine screening for ovarian cancer results in false-positive test results among 9.6% of those screened; of those with false-positive results who had surgery, the complication rate

    10. Ovarian Germ Cell Tumors Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Description of the Evidence

      PathogenesisThe pathogenesis of ovarian carcinoma remains unclear. Several theories have been proposed to explain the epidemiology of ovarian cancer including the theory of incessant ovulation,[1,2] gonadotropin stimulation,[3] excess androgenic stimulation,[4] and inflammation.[5] Associated risk factors for ovarian cancer support some or all of these hypotheses. Oral contraceptive use is consistently associated with a decreased risk of ovarian cancer and may operate through preventing the trauma from repeated ovulation by lowering exposure to gonadotropins. No one theory, however, explains all the associated risk factors.Protective Factors Factors associated with a decreased risk of ovarian cancer include: (1) using oral contraceptives, (2) having and breastfeeding children, (3) having a bilateral tubal ligation or hysterectomy, and (4) having a prophylactic oophorectomy.Oral contraceptives Multiple studies have consistently demonstrated a decrease in

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