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Ovarian Cancer Health Center

Medical Reference Related to Ovarian Cancer

  1. Ovarian Low Malignant Potential Tumors Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Early-Stage Ovarian Low Malignant Potential Tumors

    The value of complete staging has not been demonstrated for early-stage cases, but the opposite ovary should be carefully evaluated for evidence of bilateral disease. Although the impact of surgical staging on therapeutic management is not defined, in a study, 7 of 27 patients with presumed localized disease were upstaged following complete surgical staging.[1] In two other studies, 16% and 18% of patients with presumed localized tumors of low malignant potential were upstaged as a result of a staging laparotomy.[2,3] In one of these studies, the yield for serous tumors was 30.8% compared with 0% for mucinous tumors.[4] In another study, patients with localized intraperitoneal disease and negative lymph nodes had a low incidence of recurrence (5%), whereas patients with localized intraperitoneal disease and positive lymph nodes had a statistically significantly higher incidence of recurrence (50%).[5]In early-stage disease (stage I or II), no additional treatment is indicated for a

  2. Ovarian Cancer Prevention (PDQ®): Prevention - Health Professional Information [NCI] - Significance

    Incidence and Mortality In 2013, it is estimated that 22,240 new cases of ovarian cancer will be diagnosed and 14,030 deaths due to ovarian cancer will occur. Incidence rates have been relatively stable since 1992. Death rates for ovarian cancer decreased by 2.0% per year from 2005 to 2009.[1]For the general population of women, the lifetime risk of developing ovarian cancer is 1.39%; the lifetime risk of dying from ovarian cancer is 1.04%.[2] Some women are at an increased risk due to an inherited susceptibility to ovarian cancer with the magnitude of that risk depending on the affected gene and specific mutation. Underlying ovarian cancer risk can be assessed through accurate pedigrees and/or genetic markers of risk. Because of uncertainties about cancer risks associated with specific gene mutations, genetic information may be difficult to interpret outside of families with a high incidence of ovarian cancer. Three inherited ovarian cancer susceptibility syndromes have been

  3. Ovarian Low Malignant Potential Tumors Treatment (PDQ®): Treatment - Patient Information [NCI] - Stages of Ovarian Low Malignant Potential Tumors

    After ovarian low malignant potential tumor has been diagnosed, tests are done to find out if abnormal cells have spread within the ovary or to other parts of the body.The process used to find out whether abnormal cells have spread within the ovary or to other parts of the body is called staging. The information gathered from the staging process determines the stage of the disease. It is important to know the stage in order to plan treatment. Certain tests or procedures are used for staging. Staging laparotomy (a surgical incision made in the wall of the abdomen to remove ovarian tissue) may be used. Most patients are diagnosed with stage I disease. The following stages are used for ovarian low malignant potential tumor: Stage IIn stage I, the tumor is found in one or both ovaries. Stage I is divided into stage IA, stage IB, and stage IC. Stage IA: The tumor is found inside a single ovary.Stage IB: The tumor is found inside both ovaries.Stage IC: The tumor is found inside one or both

  4. Ovarian Cancer Screening (PDQ®): Screening - Health Professional Information [NCI] - About This PDQ Summary

    Purpose of This SummaryThis PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about ovarian cancer screening. It is intended as a resource to inform and assist clinicians who care for cancer patients. It does not provide formal guidelines or recommendations for making health care decisions.Reviewers and UpdatesThis summary is reviewed regularly and updated as necessary by the PDQ Screening and Prevention Editorial Board, which is editorially independent of the National Cancer Institute (NCI). The summary reflects an independent review of the literature and does not represent a policy statement of NCI or the National Institutes of Health (NIH). Board members review recently published articles each month to determine whether an article should:be discussed at a meeting,be cited with text, orreplace or update an existing article that is already cited.Changes to the summaries are made through a consensus process in

  5. Ovarian Germ Cell Tumors Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Options By Stage

    A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your doctor for clinical trials that are not listed here but may be right for you.Stage I Ovarian Germ Cell TumorsTreatment depends on whether the tumor is a dysgerminoma or another type of ovarian germ cell tumor. Treatment of dysgerminoma may include the following: Unilateral salpingo-oophorectomy with or without lymphangiography or CT scan.Unilateral salpingo-oophorectomy followed by observation.Unilateral salpingo-oophorectomy followed by radiation therapy.Unilateral salpingo-oophorectomy followed by chemotherapy.Treatment of other ovarian germ cell tumors may be either: unilateral salpingo-oophorectomy followed by careful observation; orunilateral salpingo-oophorectomy, sometimes followed by combination chemotherapy.Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting

  6. Ovarian Epithelial Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - Stages of Ovarian Epithelial Cancer

    After ovarian cancer has been diagnosed, tests are done to find out if cancer cells have spread within the ovaries or to other parts of the body. The process used to find out whether cancer has spread within the ovaries or to other parts of the body is called staging. The information gathered from the staging process determines the stage of the disease. It is important to know the stage in order to plan treatment. The results of the tests used to diagnose ovarian cancer are often also used to stage the disease. (See the General Information section.)There are three ways that cancer spreads in the body.The three ways that cancer spreads in the body are:Through tissue. Cancer invades the surrounding normal tissue.Through the lymph system. Cancer invades the lymph system and travels through the lymph vessels to other places in the body.Through the blood. Cancer invades the veins and capillaries and travels through the blood to other places in the body.When cancer cells break away from the

  7. Ovarian Low Malignant Potential Tumors Treatment (PDQ®): Treatment - Patient Information [NCI] - Changes to This Summary (08 / 17 / 2012)

    The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.Editorial changes were made to this summary.

  8. Ovarian Cancer Screening (PDQ®): Screening - Patient Information [NCI] - Changes to This Summary (08 / 08 / 2013)

    The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above. Changes were made to this summary to match those made to the health professional version.

  9. Ovarian Epithelial Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage III and Stage IV Ovarian Epithelial Cancer Treatment

    Treatment options for patients with all stages of ovarian epithelial cancer have consisted of surgery followed by chemotherapy.SurgeryPatients diagnosed with stage III and stage IV disease are treated with surgery and chemotherapy; however, the outcome is generally less favorable for patients with stage IV disease. The role of surgery for patients with stage IV disease is unclear, but in most instances, the bulk of the disease is intra-abdominal, and surgical procedures similar to those used in the management of patients with stage III disease are applied. The options for intraperitoneal (IP) regimens are also less likely to apply both practically (as far as inserting an IP catheter at the outset) and theoretically (aimed at destroying microscopic disease in the peritoneal cavity) in patients with stage IV disease. Surgery has been used as a therapeutic modality and also to adequately stage the disease. Surgery should include total abdominal

  10. Ovarian Germ Cell Tumors Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage III Ovarian Germ Cell Tumors

    DysgerminomasStandard treatment options:Total abdominal hysterectomy and bilateral salpingo-oophorectomy.Unilateral salpingo-oophorectomy with adjuvant chemotherapy.For patients with stage III dysgerminoma, total abdominal hysterectomy and bilateral salpingo-oophorectomy are recommended with removal of as much gross tumor as can be done safely without resection of portions of the urinary tract or large segments of the small or large bowel. Patients who want to preserve fertility may be treated with unilateral salpingo-oophorectomy if chemotherapy is to be employed.[1,2,3,4,5] (Refer to the PDQ summary on Sexuality and Reproductive Issues for more information on fertility.)Combination chemotherapy with bleomycin, etoposide, and cisplatin (BEP) can cure the majority of such patients. In a report of results from two Gynecologic Oncology Group (GOG) trials, 19 of 20 patients with incompletely resected tumors who were treated with BEP or cisplatin, vinblastine, and bleomycin (PVB) were

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