Treatment of recurrent ovarian epithelial cancer may include the following:Chemotherapy using one or more anticancer drugs, with or without surgery.A clinical trial of surgery.A clinical trial of targeted therapy.Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with recurrent ovarian epithelial cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.
DysgerminomasStandard treatment options:Unilateral salpingo-oophorectomy with or without lymphangiography or computed tomography (CT).Unilateral salpingo-oophorectomy followed by observation.Unilateral salpingo-oophorectomy with adjuvant radiation therapy or chemotherapy.For patients with stage I dysgerminoma, unilateral salpingo-oophorectomy conserving the uterus and opposite ovary is accepted treatment of the younger patient who wants to preserve fertility or a pregnancy. Postoperative lymphangiography or CT is indicated before treatment decisions are made for patients who have not had careful surgical and pathological examination of pelvic and para-aortic lymph nodes during surgery. (Refer to the PDQ summary on Sexuality and Reproductive Issues for more information on fertility.)Patients who have been completely staged and have stage IA tumors may be observed carefully after surgery without adjuvant treatment. About 15% to 25% of these patients will relapse, but they can be treated
Standard treatment options for patients with ovarian germ cell tumors include:Surgery.Chemotherapy.Radiation therapy.Patients may be treated with unilateral salpingo-oophorectomy or total abdominal hysterectomy and bilateral salpingo-oophorectomy.All patients except those with stage I, grade I immature teratoma and stage IA dysgerminoma require postoperative chemotherapy. With platinum-based combination chemotherapy, the prognosis for patients with endodermal sinus tumors, immature teratomas, embryonal carcinomas, choriocarcinomas, and mixed tumors containing one or more of these elements has improved dramatically. As new and more effective drugs are developed, many of these patients will be candidates for newer clinical trials.Treatment options under clinical evaluation for patients with ovarian germ cell tumors include:High-dose chemotherapy with bone marrow transplant.New treatment options.References: Gershenson DM, Morris M, Cangir A, et al.: Treatment of malignant germ cell
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.Editorial changes were made to this summary.
For general cancer information and other resources from the National Cancer Institute, see the following:What You Need to Know About™ CancerUnderstanding Cancer Series: CancerCancer StagingChemotherapy and You: Support for People With CancerRadiation Therapy and You: Support for People With CancerCoping with Cancer: Supportive and Palliative CareQuestions to Ask Your Doctor About CancerCancer LibraryInformation For Survivors/Caregivers/Advocates
About PDQPhysician Data Query (PDQ) is the National Cancer Institute's (NCI's) comprehensive cancer information database. The PDQ database contains summaries of the latest published information on cancer prevention, detection, genetics, treatment, supportive care, and complementary and alternative medicine. Most summaries come in two versions. The health professional versions have detailed information written in technical language. The patient versions are written in easy-to-understand, nontechnical language. Both versions have cancer information that is accurate and up to date and most versions are also available in Spanish.PDQ is a service of the NCI. The NCI is part of the National Institutes of Health (NIH). NIH is the federal government's center of biomedical research. The PDQ summaries are based on an independent review of the medical literature. They are not policy statements of the NCI or the NIH.Purpose of This SummaryThis PDQ cancer information summary has current
A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your doctor for clinical trials that are not listed here but may be right for you.Stage I Ovarian Germ Cell TumorsTreatment depends on whether the tumor is a dysgerminoma or another type of ovarian germ cell tumor. Treatment of dysgerminoma may include the following: Unilateral salpingo-oophorectomy with or without lymphangiography or CT scan.Unilateral salpingo-oophorectomy followed by observation.Unilateral salpingo-oophorectomy followed by radiation therapy.Unilateral salpingo-oophorectomy followed by chemotherapy.Treatment of other ovarian germ cell tumors may be either: unilateral salpingo-oophorectomy followed by careful observation; orunilateral salpingo-oophorectomy, sometimes followed by combination chemotherapy.Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting
Screening is looking for cancer before a person has any symptoms. This can help find cancer at an early stage. When abnormal tissue or cancer is found early,it may be easier to treat. By the time symptoms appear,cancer may have begun to spread. Scientists are trying to better understand which people are more likely to get certain types of cancer. They also study the things we do and the ...