Skip to content
My WebMD Sign In, Sign Up

Ovarian Cancer Health Center

Font Size

New Ovarian Cancer Treatment Working

Combination Drug Therapy Doubles Ovarian Cancer Survival
By
WebMD Health News
Reviewed by Louise Chang, MD

Nov. 15, 2006 -- Aggressive combination therapy for ovarian cancer is worth the cost and toxicity, a new study shows.

The new treatment more than doubles survival time from two and a half years to five and a half years.

Ovarian cancer is a killer. It's often well advanced by the time it's diagnosed. Without treatment, most patients die in two and a half years.

In patients who can tolerate it, doctors today use a combination of platinum-based chemotherapy plus drugs called taxanes. Most recently, they've begun injecting the drugs directly into the abdominal cavity.

It seems to work better than older treatments. But might less aggressive therapy work just as well? A team of researchers from Britain, Greece, and the U.S. decided to find out.

Maria Kyrgiou, MD, of Queen Charlotte's and Chelsea Hospital in London, and colleagues analyzed 198 clinical studies. The studies, conducted between 1971 and 2006, tested 120 different chemotherapy regimens on 38,440 women with ovarian cancer.

The bottom line: Compared with single-agent chemotherapy without platinum-based drugs or taxanes, the new combination -- given by abdominal injection -- cuts the risk of death by more than half (55%). When given in other ways, the combination cuts death risk by 42%.

Platinum-based drug combinations without taxanes cut deaths by 40% when given by abdominal injection and by 30% when given in other ways. Taxanes alone don't do much good.

"Compared with the early days, when neither platinum nor taxanes were available and chemotherapy was clearly no better than supportive care [in terms of death] ... survival can now be more than doubled using currently available regimens," Kyrgiou and colleagues conclude.

The researchers note that not all patients will be able to tolerate aggressive combination therapy.

"These benefits should be tailored to the individual patient and balanced against tolerability," they warn.

Kyrgiou and colleagues report their findings in the Nov. 15 issue of the Journal of the National Cancer Institute.

Today on WebMD

what is your cancer risk
HEALTH CHECK
ovarian cancer overview slideshow
SLIDESHOW
 
cancer fighting foods
SLIDESHOW
15 Cancer Symptoms Women Ignore
FEATURE
 
Integrative Medicine Cancer Quiz
QUIZ
Lifestyle Tips for Depression Slideshow
SLIDESHOW
 
Screening Tests for Women
Slideshow
Graphic of ovaries within reproductive system
VIDEO
 
Ovarian Cancer Marker
VIDEO
Pets Improve Your Health
SLIDESHOW
 
Vitamin D
SLIDESHOW
Healthy meal with salmon
Article