March 9, 2011 (Orlando, Fla.) -- Nearly one in four ovarian cancers are inherited, say researchers who are developing a gene-based blood test to identify women with these hereditary cancers.
The test, which looks for variations in 22 genes known or suspected to predispose women to ovarian cancer, isn't ready for prime time yet.
But if results of the new study can be replicated and the test becomes commercially available, it would be a big advance over the current genetic screen, says study head Elizabeth Swisher, MD, an expert in medical genetics at the University of Washington in Seattle.
The current test, which screens for the BRCA1 and BRCA2 genes, only spots about 10% to 15% of ovarian cancers, she tells WebMD.
The new study included 284 women who were undergoing surgery to remove an ovarian or fallopian tube tumor. All provided blood samples for DNA testing.
A total of 24% had a mutation in one or more of the 22 genes, which included BRCA 1 and BRCA2.
About three-fourths of women who tested positive for a mutation had a family history of breast or ovarian cancer. (The same genes that increase a woman's risk of ovarian cancer are usually associated with increased breast cancer risk, too.)
The results were presented at the Society of Gynecologic Oncology's Annual Meeting on Women's Cancer.