Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started
My Medicine

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Ovarian Cancer Health Center

Font Size

Antibody Could Help Predict Ovarian Cancer

Researchers Say Discovery Could Lead to New Tests and Treatments
WebMD Health News
Reviewed by Laura J. Martin, MD

Aug. 17, 2011 -- Researchers say they've discovered a marker that could one day help doctors spot women who may be at high risk for ovarian cancer.

The marker is an antibody to a protein, called mesothelin, which is overproduced by cancer cells.

The study found the antibody was present in high levels in the blood of many women who were infertile because of problems with their ovaries.

Researchers think elevated antibody levels may indicate that the body's immune system is attacking its own ovaries, a condition called autoimmune oophoresis.

Autoimmune oophoresis is known to cause infertility, and researchers think it may also lead to some cases of ovarian cancer, though it's not clear how.

"That's the 64 million dollar question," says study researcher Judith L. Luborsky, PhD, professor of pharmacology, obstetrics and gynecology and preventive medicine at Rush University Medical Center in Chicago.

"The question we don't have an answer to is what role the immune system actually plays in the initiation [of cancer]," she tells WebMD.

While the idea is interesting, experts who were not involved in the research say the study only looked at one moment in time, so it's tough to draw conclusions about what elevated antibody levels may mean and it doesn't prove that elevated antibodies cause cancer.

"It sort of creates another hypothesis," says Mary Daly, MD, PhD, professor and chair of the department of clinical genetics at Fox Chase Cancer Center, in Philadelphia.

"There's a lot of literature linking infertility with an increased risk for ovarian cancer, but very little to suggest why that would be," Daly says. "What is it about women who have problems getting pregnant that puts their ovaries at increased risk for ovarian cancer?"

This study may help to direct research into one of the possible explanations for that, she says.

Infertility and Ovarian Cancer

For the study, which is published in the journal Cancer Epidemiology, Biomarkers & Prevention, researchers looked for the antibody in the blood of women who were unable to conceive a baby after a year of unprotected sex, a clinically accepted definition of infertility.

Today on WebMD

Ovarian cancer illustration
What are the symptoms?
doctory with x-ray
Get to know the Symptoms.
cancer cell
HPV is the top cause. Find out more.
Lung cancer xray
See it in pictures, plus read the facts.
Integrative Medicine Cancer Quiz
Lifestyle Tips for Depression Slideshow
Screening Tests for Women
Graphic of ovaries within reproductive system
Ovarian Cancer Marker
Pets Improve Your Health
Vitamin D
Healthy meal with salmon