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Ovarian Cancer Prevention (PDQ®): Prevention - Patient Information [NCI] - Ovarian Cancer Prevention

Avoiding risk factors and increasing protective factors may help prevent cancer.

Avoiding cancer risk factors may help prevent certain cancers. Risk factors include smoking, being overweight, and not getting enough exercise. Increasing protective factors such as quitting smoking, eating a healthy diet, and exercising may also help prevent some cancers. Talk to your doctor or other health care professional about how you might lower your risk of cancer.

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Treatment Options for Recurrent or Persistent Ovarian Epithelial Cancer

Treatment of recurrent ovarian epithelial cancer may include the following: Chemotherapy using one or more anticancer drugs, with or without surgery. A clinical trial of surgery. A clinical trial of targeted therapy. Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with recurrent ovarian epithelial cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type...

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The following risk factors may increase the risk of ovarian cancer:

Family history of ovarian cancer

A woman whose mother or sister had ovarian cancer has an increased risk of ovarian cancer. A woman with two or more relatives with ovarian cancer also has an increased risk of ovarian cancer.

Inherited risk

The risk of ovarian cancer is increased in women who have inherited certain changes in the following genes:

  • BRCA1 or BRCA2 genes.
  • Genes that are linked to hereditary nonpolyposis colorectal cancer (HNPCC; Lynch syndrome).

Hormone replacement therapy

The use of estrogen -only hormone replacement therapy (HRT) after menopause increases the risk of ovarian cancer. The longer estrogen replacement therapy is used, the greater the risk may be. It is not clear whether the risk of ovarian cancer is increased with the use of HRT that has both estrogen and progestin.

Fertility drugs

The use of fertility drugs may be linked to an increased risk of ovarian cancer.

Obesity

Having too much body fat, especially during the teenage years, is linked to an increased risk of ovarian cancer. Being obese is linked to an increased risk of death from ovarian cancer.

Height

Being taller than 5 feet 8 inches is linked to an increased risk of ovarian cancer.

The following protective factors may decrease the risk of ovarian cancer:

Oral contraceptives

The use of oral contraceptives ("the pill") lowers ovarian cancer risk. The longer oral contraceptives are used, the lower the risk may be. The decrease in risk may last up to 25 years after a woman has stopped using oral contraceptives.

Taking oral contraceptives increases the risk of blood clots. This risk is higher in women who also smoke. There may be a slight increase in a woman's risk of breast cancer during the time she is taking oral contraceptives. This risk decreases over time.

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