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    Botox May Cut Knee Osteoarthritis Pain

    Study Shows Injecting Botox May End or Delay Need for Joint Replacement Surgery
    WebMD Health News
    Reviewed by Louise Chang, MD

    Nov. 14, 2006 (Washington, D.C.) -- Botox shots may do more than get rid of wrinkles. A new study shows Botox may decrease the pain of knee osteoarthritis (OA) and potentially prevent or forestall the need for knee replacement surgery.

    The preliminary research was presented at the 2006 annual meeting of the American College of Rheumatology.

    Injecting Botox directly into the knee joint relieved pain and improved function among people with severe knee osteoarthritis after one month, says researcher Maren Mahowald, MD. She is the rheumatology section chief at the Minneapolis Veteran’s Affairs Medical Center and professor of medicine at the University of Minnesota in Minneapolis. Mahowald now plans to evaluate the participants after three and six months.

    Botox is a purified form of botulinum toxin type A and has been used to treat wrinkles and creases on the face. It is currently FDA-approved to treat other conditions including excessive sweating, eye disorders, and certain neurologic conditions. Botox is being studied for treatment of headache, ringing in the ears, overactive bladder, diabetic nerve pain, and more.

    Pain Reduction

    The new study comprised 37 people with moderate and severe knee osteoarthritis. Participants received 100 units of Botox with the anesthetic lidocaine or a dummy injection with lidocaine directly into their knee joints.

    After one month, people with severe pain showed a 28% decrease in pain and a 25% improvement in function. By contrast, people with severe knee pain who received a placebo did not show a significant decrease in pain.

    Botox injections had almost no effect among people with moderate pain, the study found.

    But it’s still early, Mahowald points out. ”Patients often have continued decreases in pain and improvements in function after one to two months. And I think there will be more improvements at the three-month evaluation.”

    Exactly how long the effect lasts will be determined at the six-month evaluation, she says. “People may require one to three injections per year to control knee pain, but these injections may obviate the need for knee surgery.”

    The new findings came about when researchers noticed that people with limb weakness from a stroke or polio did not develop arthritis.

    They also noticed that when people with cervical dystonia -- neck muscle stiffness and spasms -- received shots of Botox, their pain improved before their muscle contractions stopped, suggesting that Botox may have a soothing effect on pain nerves.

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