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Knee Pain Health Center

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Knee Pain May Not Be Helped by Glucosamine

Popular supplement did not reduce cartilage damage or improve joint function in study

WebMD News from HealthDay

By Robert Preidt

HealthDay Reporter

TUESDAY, March 11, 2014 (HealthDay News) -- The dietary supplement glucosamine does not slow cartilage damage in people with chronic knee pain, according to a new study.

Millions of Americans take glucosamine in an effort to treat osteoarthritis of the knee and other joints. The most common form of arthritis, osteoarthritis is related to normal wear and tear of the joints.

The new study, published online March 11 in the journal Arthritis & Rheumatology, included about 200 people with mild to moderate pain in one or both knees. They were randomly selected to drink 1,500 milligrams a day of glucosamine or a placebo added to a 16-ounce bottle of diet lemonade for 24 weeks.

MRI scans were used to assess cartilage damage in the patients' knees. Reductions in cartilage damage were no greater in the glucosamine group than in the placebo group, and taking glucosamine did not reduce knee pain, according to a journal news release.

"Our study found no evidence that drinking a glucosamine supplement reduced knee cartilage damage, relieved pain or improved function in individuals with chronic knee pain," said researcher Dr. C. Kent Kwoh, director of the University of Arizona Arthritis Center.

A 2007 survey found that 10 percent of American adults used glucosamine.

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