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Physical Pain a Sign of Depression

Pain Triples Depression Risk

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There is strong evidence that antidepressant drugs relieve pain, Raison says. It takes several weeks for these drugs to have an effect on depression. It takes just as long for them to work on pain. This suggests that they act on a brain system that underlies both depression and pain.

Raison says that clinical trials of duloxetine, Lilly's new antidepressant drug, suggest that it may be particularly effective in treating physical pain associated with depression.

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