Skip to content

    Pain Management Health Center

    Font Size
    A
    A
    A

    Pain Relievers: Questions & Answers

    Arthritis Expert Helps You Understand Risks From Pain Relievers
    By
    WebMD Health News

    Arthritis Expert Helps You Understand Risks From Pain Relievers

    Feb. 18, 2005 -- After three days of meetings, an expert FDA panel has recommended that the pain relievers Bextra and Celebrex, also called Cox-2 drugs, remain on the market. They also recommended that Vioxx be allowed back on the market. WebMD turned to arthritis expert William Shiel, MD, chief medical editor of MedicineNet.com, a WebMD company, to help you understand the drugs and their risks.

    The FDA is expected to officially act on these recommendations in the near future.

    Is the concern with Cox-2 drugs only in elderly people?

    While studies have shown heart risks in people 65 and over, the issues raised pertain to any patient with underlying risk factors for heart disease or stroke. This means not only the elderly may be at risk, but also those who have underlying heart disease or known blood vessel disease, such as atherosclerosis or calcification of blood vessels.

    Caution might be also be used for those with high blood pressure and a tendency toward fluid retention (edema). It has been shown that all anti-inflammatory drugs (like ibuprofen and Cox-2 inhibitors) can worsen blood pressure or cause fluid retention. Patients should be monitored for such side effects. Similarly, in the elderly who are at risk for kidney problems or in any patient with kidney disease, anti-inflammatory drugs should be used cautiously with close monitoring of kidney function.

    Are Cox-2 inhibitors better pain relievers than older, traditional anti-inflammatory drugs like ibuprofen and naproxen?

    No. As a group, the benefit of these drugs lies in their lower frequency of stomach and intestinal side effects, not in their effectiveness. Clinical research has shown that the Cox-2 inhibitors are essentially equivalent to traditional anti-inflammatory drugs in effectiveness. Improved effectiveness has never been the point of these medications, nor have their respective manufacturers marketed them for that purpose.

    Having said that, doctors are well aware that determining which patient is going to respond to which anti-inflammatory drug involves some trial and error. Therefore, it is convenient to have options when treating chronic pain or inflammation.

    1 | 2 | 3

    Today on WebMD

    pain in brain and nerves
    Top causes and how to find relief.
    knee exercise
    8 exercises for less knee pain.
     
    acupuncture needles in woman's back
    How it helps arthritis, migraines, and dental pain.
    chronic pain
    Get personalized tips to reduce discomfort.
     
    illustration of nerves in hand
    Slideshow
    lumbar spine
    Slideshow
     
    Woman opening window
    Slideshow
    Man holding handful of pills
    Video
     
    Woman shopping for vegetables
    Slideshow
    Sore feet with high heel shoes
    Slideshow
     
    acupuncture needles in woman's back
    Slideshow
    man with a migraine
    Slideshow