Skip to content

    Pain Management Health Center

    Font Size

    Chronic Pain On/Off Switch Found

    Discovery Raises Hope for Better Pain Treatments
    WebMD Health News
    Reviewed by Louise Chang, MD

    July 27, 2006 -- A molecular switch turns off chronic pain, Columbia University researchers report.

    The switch is an enzyme called protein kinase G or PKG. When PKG gets stuck in the "on" position, nerve cells keep sending pain signals -- long after the injury that originally caused the pain has healed. Turning PKG off stops the pain, rats studies show.

    "We're very optimistic that this discovery, and our continued research, will ultimately lead to a novel approach to pain relief for the millions suffering from chronic pain," researcher Richard Ambron, PhD, said in a news release.

    Ambron and colleague Ying-Ju Sung, PhD, have applied for patents on the pathway of chemical signals that turns PKG on. They've also applied for patents on several molecules that turn PKG off.

    Some 48 million Americans suffer from long-lasting pain. Current pain drugs don't always work -- and when they do, they can have serious side effects such as drowsiness. It's hoped that the PKG discovery will lead to a new class of pain drugs that is more effective and has fewer side effects.

    After injury, pain sensors in the body can lapse into a hyper-excited state. Long after the original injury is gone, these pain cells keep on sending intense pain signals. PKG, Ambron's team discovered, is responsible for this long-term hyper-excitability of pain sensors.

    The finding is exciting, because current pain drugs affect the brain's ability to receive pain signals from the spinal cord. Drugs that affect PKG would work much farther down the pain-signal pathway -- in the periphery of the body and not in the brain.

    The study appears in the August issue of the journal Neuroscience.

    Today on WebMD

    pain in brain and nerves
    Top causes and how to find relief.
    knee exercise
    8 exercises for less knee pain.
    acupuncture needles in woman's back
    How it helps arthritis, migraines, and dental pain.
    chronic pain
    Get personalized tips to reduce discomfort.
    illustration of nerves in hand
    lumbar spine
    Woman opening window
    Man holding handful of pills
    Woman shopping for vegetables
    Sore feet with high heel shoes
    acupuncture needles in woman's back
    man with a migraine