Cox-2 Use Is Down, but Ulcers Are Up
Patients Turn to Traditional NSAID Painkillers but Skip Drugs That Protect Their Stomachs
WebMD News Archive
Increase in Ulcers in 2005 continued...
In 2004, just 14% of patients were not receiving gastroprotection. By
contrast, 79% of patients were not receiving gastroprotection in 1997, the
study shows. This decline coincided with the eradication of H.
pylori infection as a major cause of ulcers as well as better medical care
including the growing use of Cox-2 inhibitors.
"It started getting smaller and as Cox-2 inhibitors were introduced, the
gap became even smaller," Singh says.
In fact, the rate of serious GI complications dropped from 682 per 100,000
prescriptions in 1997 to 357 per 100,000 in 2004. The sharpest decline occurred
from 1999 to 2000. There were 570 GI complications per 100,000 prescriptions in
1999 and 423 GI complications per 100,000 prescriptions in 2000.
This drop corresponded with a large decline in the gastroprotection gap from
55.6% in 1999 to 25.2% in 2000, the study showed.