Lyrica Eases Pain From Knee Surgery
Study Shows the Fibromyalgia Drug Also Cuts Pain After Knee Replacement Surgery
WebMD News Archive
Lyrica vs. Placebo
The study involved 240 patients undergoing knee replacement surgery who were
divided into two groups.
Half the patients were treated with 300 milligrams of Lyrica two hours
before surgery and 150 milligrams of the drug twice a day for two weeks
following surgery. The rest of the patients received placebo treatments given
at the same time intervals.
Neither the patients nor the doctors and nurses administering the drugs knew
which treatment the patients were getting. All the study participants also
received standard pain medication following surgery.
Six months after surgery, there were no complaints of chronic neuropathic
pain among patients treated with the fibromyalgia drug, while 5.3% of
placebo-treated patients continued to have pain.
The Lyrica-treated patients also had a greater range of motion in surgically
treated knees following surgery.
Buvanendran says the drug is now routinely given to patients undergoing knee
replacement surgery at Rush University Medical Center.
Rush surgeon Aaron G. Rosenberg, MD, tells WebMD that the study is not the
first to show that drugs given to patients around the time of surgery can
improve long-term outcomes.
Rosenberg was not involved with the latest trial, but he did participate in
a 2003 study which showed improved long-term outcomes among knee replacement
patients treated with a Cox-2-type pain reliever immediately before and after
"We showed that patients treated for a couple of weeks with a relatively
cheap anti-inflammatory had better range of motion a month after surgery,"
he says. "That is important because the quicker knee surgery patients get
moving the better."