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Pain 'Signature' Spotted on Brain MRIs

Scientists could distinguish physical from emotional pain, discomfort in study

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And since fMRI scans are expensive, Wang noted, studies would have to show that the imaging actually benefits patients before it would be routinely used in the real world.

The study involved a total of 114 healthy young adults who took part in different phases of the research. First, Wager's team found that fMRI scans were able to pick up a reliable pain signature in the brain when volunteers had painful heat applied to their forearms.

The researchers then found that the signature was different and stronger than brain activity that popped up in response to the sensation of warmth, or to anticipation or remembrance of the pain.

More interesting, Wager said, was that the signature seemed to be unique to physical pain. In one set of experiments, the researchers had heartbroken volunteers who'd recently gone through a breakup look at a photo of their ex-partner. That did trigger activity in brain regions related to physical pain, but the signature linked to heat-induced pain remained distinct.

Wager agreed that much more work needs to be done, and his team is already looking at whether the neurologic signature holds up in other types of pain.

For his part, Wang pointed out that pain comes in many different forms, with causes ranging from inflammation to nerve damage. And chronic pain, in particular, is very complex, study author Wager noted.

Whether fMRI is ever used to diagnose pain, studies like this could help researchers gain a better understanding of the "biology of pain," Wang said. "Our understanding of pain is still fairly rudimentary."

A better understanding of pain, Wager said, will hopefully lead to better ways to manage it.

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