NSAIDs are nonsteroidal anti-inflammatory drugs. They include both OTC and prescription types; Advil, Bayer, Motrin, Aleve, and Celebrex are a few familiar brands. NSAIDs reduce swelling and relieve pain and fever. Aspirin is an NSAID used to help prevent heart problems or stroke. Side effects include heartburn, upset stomach, rashes, and more. Follow the links below to find WebMD's comprehensive coverage about how NSAIDs work, uses, side effects, and more.