Some people inherit one sickle cell
gene and one other defective
hemoglobin gene, resulting in various types of
sickling disorders. These disorders range from mild to severe.
Sickle cell diseaseSickle cell disease (hemoglobin SS disease) occurs when both genes produce
hemoglobin S. This person typically has symptoms of
anemia, mild to life-threatening complications, and a
shortened life span.
occurs when a person has one hemoglobin S gene and another gene that causes the
body to produce less hemoglobin than normal. This person may have mild to
severe sickle cell disease.
Hemoglobin SC disease occurs when a person has one hemoglobin S gene and one abnormal
hemoglobin C gene. This person may have generally milder symptoms and a longer
life span than a person with sickle cell disease but still may become seriously
Hemoglobin SE disease occurs when a person has one hemoglobin S gene and one abnormal
hemoglobin E gene. This person may have mild anemia. Most people do not have symptoms.
Hemoglobin SO disease and
hemoglobin SD disease occur when a person has one
hemoglobin S gene and one abnormal hemoglobin O or hemoglobin D gene. This
person may experience all sickle cell disease symptoms, ranging from mild to
In this article
This information is produced and provided by the National
Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National
Institute via the Internet web site at http://
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WebMD Medical Reference from Healthwise
March 12, 2014
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