Skip to content

Pain Management Health Center

Unexplained Nerve Pain

Font Size
A
A
A

If you have nerve pain, you know that it can take many forms: burning, tingling, electric, and pins-and-needles. But if you have no idea what's causing the pain, you're not alone. Millions of people have unexplained nerve pain. While traditional medicine can offer some relief, there are a number of other ways to lessen the pain.

Known Causes of Nerve Pain

Nerve pain is caused by damage to the nerve. More than 50 medical conditions, drugs, and toxins are known to cause nerve damage, including:

  • Diabetes
  • Human immunodeficiency virus (HIV) infection
  • Celiac disease
  • Trauma
  • Amyloidosis
  • Fabry's disease
  • Medications, including B6 (pyridoxine), isoniazid, HIV drugs, or chemotherapy
  • Toxins, such as heavy alcohol use
  • Autoimmune conditions, such as lupus and vasculitis
  • Vitamin B12 deficiency
  • Some cancers, such as lymphoma or myeloma
  • Lyme disease

Once a nerve is damaged, it is more likely to start behaving abnormally. It may become quiet and send no information, which causes numbness. Or it may send excessive and inappropriate pain messages.

Searching for Causes of Nerve Pain

For many people, the cause of nerve pain cannot be identified even after extensive testing. This is called unexplained (idiopathic) nerve pain, or idiopathic neuropathy. Unexplained nerve pain may still be due to nerve damage that occurred at some point, but current medical knowledge and testing can't say how, when, or why.

Between 15 million to 20 million Americans are believed to have unexplained nerve pain -- about one in 10 people over age 40. It's most likely to occur in people over age 60.

In some studies, almost half of the participants with unexplained nerve pain also had prediabetes. Some experts believe that the elevated blood sugars of prediabetes may be the main cause of this.

Other studies have found that metabolic syndrome -- the combination of high blood pressure, abnormal cholesterol levels, obesity, and prediabetes -- is also common in people with unexplained nerve pain. These factors may contribute to the pain.

Symptoms of Unexplained Nerve Pain

Idiopathic peripheral neuropathy, like diabetic neuropathy, usually causes numbness in the hands and feet. The numbness may go unnoticed if it causes no pain.

Today on WebMD

pain in brain and nerves
Top causes and how to find relief.
knee exercise
8 exercises for less knee pain.
 
acupuncture needles in woman's back
How it helps arthritis, migraines, and dental pain.
chronic pain
Get personalized tips to reduce discomfort.
 
illustration of nerves in hand
Slideshow
lumbar spine
Slideshow
 
Woman opening window
Slideshow
Man holding handful of pills
Video
 
Woman shopping for vegetables
Slideshow
Sore feet with high heel shoes
Slideshow
 
acupuncture needles in woman's back
Slideshow
man with a migraine
Slideshow