Skip to content

    Health & Baby

    Font Size

    Some Over-the-Counter Pain Drugs Linked to Severe Newborn Illness

    WebMD Health News

    March 5, 2001 -- If you're pregnant, your life can seem like an unending list of "don'ts." You probably know to avoid unnecessary medications. But what about that aspirin or ibuprofen (Advil, Motrin) you take for a nagging headache? Since these medications are available without a prescription, do they even count? Absolutely.

    Aspirin, ibuprofen, and naproxen belong to a medication class known as nonsteroidal anti-inflammatory drugs, also called NSAIDs. These medications are often used to treat aches and pains, but because they're often available without prescription, many people don't think of them as drugs.

    However, just because you don't need a prescription to get them doesn't necessarily mean that they're safe to use -- especially when you're pregnant.

    According to new research in the March issue of Pediatrics, there may be a link between NSAID use by mothers and a serious respiratory condition in newborns known as persistent pulmonary hypertension. This condition is characterized by a stiffening of the blood vessels in the lungs. Infants with pulmonary hypertension are typically treated in the intensive care unit, often require ventilator support, and are at high risk of dying from this illness.

    In the study, investigators compared the first bowel movements of infants with pulmonary hypertension to those of healthy infants. They found that the affected infants were far more likely to test positive for exposure to at least one NSAID drug, typically aspirin.

    An infant's first bowel movement contains a substance called meconium, which begins forming relatively early in pregnancy. Because meconium is typically not passed until after birth, medications the mother has taken throughout the pregnancy may be present in the substance.

    Among all of the infants with pulmonary hypertension, the meconium analysis was positive for NSAID exposure for nearly half. However, less than 28% of the mothers had disclosed that they had taken any NSAIDs during the pregnancy.

    "Pregnant women should be cautious in taking any drugs, particularly if they do not know what they contain," co-author Enrique M. Ostrea, MD, tells WebMD. "[They] should know of the risks associated with NSAIDs, in particular. More regulation of labeling would also help, so that the mothers know the risks and benefits of taking [these] medications." Ostrea is a professor of pediatrics at Wayne State University School of Medicine in Detroit, where he is chief of pediatrics at Hutzel Hospital.

    Baby's First Year Newsletter

    Because every week matters, get expert advice and facts on what to expect in your baby's first year.

    Today on WebMD

    mother on phone holding baby
    When you should call 911.
    parents and baby
    Unexpected ways your life will change.
    baby acne
    What’s normal – and what’s not.
    baby asleep on moms shoulder
    Help your baby get the sleep he needs.

    mother holding baby at night
    mother with sick child
    Chinese mother breast feeding newborn baby girl
    Track Your Babys Vaccines
    Baby Napping 10 Dos And Donts
    Mother with her baby boy
    baby in crib
    baby gear slideshow