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    Mom's Diabetes, Obesity Tied to Higher Autism Risk

    Combination may nearly quadruple risk, researchers say, but their review did not prove cause-and-effect

    WebMD News from HealthDay

    By Alan Mozes

    HealthDay Reporter

    FRIDAY, Jan. 29, 2016 (HealthDay News) -- Mothers-to-be who are both obese and diabetic have a higher risk of giving birth to a child with autism than healthy women, a new study suggests.

    The two conditions in combination nearly quadrupled the risk that a child would receive an autism diagnosis, said researchers who looked at more than 2,700 mother-child pairs.

    Individually, maternal obesity or diabetes was linked to twice the odds of giving birth to a child with autism compared to mothers of normal weight without diabetes, the study found.

    "The finding is not a total surprise," said study author Dr. Xiaobin Wang, director of the Center on Early Life Origins of Disease at Johns Hopkins University in Baltimore. "Many studies have shown that maternal obesity and diabetes have an adverse impact on developing fetuses and their long-term metabolic health."

    "Now we have further evidence that maternal obesity and diabetes also impact the long-term neural development of their children," added Wang.

    The study doesn't prove that obesity and diabetes in tandem actually cause the autism, however. It only found an association.

    The study, which tracked more than 2,700 births, adds to evidence that autism risk may start before birth, the researchers said.

    In the United States, more than one-third of women of reproductive age are obese, while almost 10 percent struggle with diabetes, the study authors said in background notes.

    Prevalence of autism -- now affecting 1 in 68 U.S. kids -- has skyrocketed since the 1960s, alongside the incidence of obesity and diabetes in women of reproductive age, the authors point out.

    Their study, published online Jan. 29 in the journal Pediatrics, involved children born at Boston Medical Center between 1998 and 2014.

    All the babies' mothers were interviewed one to three days following delivery, with their obesity and diabetes status noted. In turn, their babies were tracked for an average of six years.

    Almost 4 percent of the babies were diagnosed on the autism spectrum. About 5 percent had some form of intellectual disability, and nearly one-third were diagnosed with another developmental disability. Some were diagnosed with more than one condition.

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