New Parkinson's Treatment Is Safe, But Is It Effective?
WebMD News Archive
April 24, 2000 -- A preliminary study of a new drug for Parkinson's disease
suggests it is safe to use, but whether or not it actually works is another
When tested in animals together with other medications, remacemide
hydrochloride appears to reduce Parkinson's disease symptoms. However, it does
not decrease symptoms when used on its own in humans, according to an article
in the April 25 issue of Neurology.
Parkinson's disease is a progressive disease that causes difficulty in
walking and moving, stiff muscles, and tremors. It typically affects the
elderly, but can affect adults in their 30s and 40s and occasionally affects
children. It is caused by a decrease of cells in the brain that produce a
chemical called dopamine, which is important for regulating the body's
Parkinson's disease is often treated with levodopa, a drug that helps
replace dopamine. Because of the side effects of levodopa, which is sold under
the brand names Dopar and Larodopa, other drugs have also been developed.
Certain brain surgeries have also relieved symptoms in some patients.
Currently, there is no cure for Parkinson's disease.
Research has suggested that some of the symptoms of Parkinson's disease may
be caused by overactivity of a chemical in the brain called glutamate. Stanley
Fahn, MD, who served on the steering committee of the Parkinson Study Group,
and the author of the paper, tells WebMD that remacemide may work to block one
of the glutamate receptors in the brain. Fahn is also a professor of neurology
at Columbia University School of Medicine in New York City.
In this study, 200 patients with early Parkinson's disease who were not
taking levodopa or other dopamine drugs received varying levels of remacemide
hydrochloride or a sugar pill twice a day for five weeks.
While some patients reported nausea and dizziness, there were no serious
side effects. Those who experienced strong side effects at higher dosage levels
were allowed to divide the medication into four doses. However, 85% of the
patients were able to tolerate the drug.
Although previous studies in animals had shown improvement of symptoms,
there was no evidence of that in the patients taking remacemide for this