Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Parkinson's Disease Health Center

Font Size

Ibuprofen May Protect Against Parkinson's

Risk of Parkinson's Disease Reduced 35% in Regular Users
WebMD Health News

April 14, 2005 (Miami Beach, Fla.) -- In the latest study to suggest that anti-inflammatory drugs may protect against brain disorders, researchers have found that regular use of ibuprofen may lower a person's risk of Parkinson's disease.Parkinson's disease.

But the findings are still preliminary and people should not start popping the common painkiller in hopes of warding off the progressive brain disorder, Harvard researchers say.

Parkinson's disease is caused by the loss of brain cells that control movement. Symptoms includeSymptoms include shaking, rigidity, slow movements, and unsteadiness.

The findings, presented at the annual meeting of the American Academy of Neurology, came from data collected in a large study of nearly 150,000 men and women. The participants were tracked over eight-and-a-half years, during which time 413 developed Parkinson's disease.

Does Ibuprofen Stand Alone?

"Our findings showed that ibuprofen users were 35% less likely to develop Parkinson's disease than nonusers," says researcher Alberto Ascherio, MD, DrPH, associate professor of nutrition and epidemiology at Harvard School of Public Health in Boston.

Surprisingly, this benefit was only seen in patients who took ibuprofen and not those who took aspirin, other anti-inflammatory drugs,other anti-inflammatory drugs, or acetaminophen, he tells WebMD. Brand names of ibuprofen include Advil and Motrin.

The more frequently a person took ibuprofen, the greater the benefit, the study showed. Those who used ibuprofen less than twice weekly were 27% less likely to develop Parkinson's disease, while daily users were 39% less likely to develop Parkinson's.

But there was no link between the length of time that ibuprofen users had been taking the medication and Parkinson's disease, Ascherio says.

The researchers did not study whether the dose of ibuprofen had any effect on the risk of Parkinson's disease.

Age, sex, and smoking status -- known risk factors for Parkinson's diseaseknown risk factors for Parkinson's disease -- could not explain the results.

Surprising Findings

Ascherio says he was "somewhat surprised" that the benefits did not extend to aspirin or other anti-inflammatory drugs.

It could be a statistical anomaly due to the fact that three-quarters of anti-inflammatory users in the study took ibuprofen. "Maybe we only had the statistical power to see an effect with ibuprofen," he says.

Today on WebMD

Parkinsons disease illustration
Causes, symptoms, and treatments.
hands on walker
How does the disease progress?
man with serious expression
8 common questions and answers.
intelligence quotient illustration
What are the advantages of DBS?
Parkinsons Disease Medications
Questions Doctor Parkinsons
Eating Right
Parkinsons Exercise
daughter consoling depressed mother
senior man's hands
Parkinsons Daily