Parkinson's Drugs: Heart Damage Link?
Researchers Raise Concerns About Damage to Heart Valves From 2 Parkinson's Drugs
Bryan Roth, MD, PhD, tells WebMD that the two Parkinson's drugs appear to
cause heart damage in the same way that the now notorious weight
loss medication fen-phen did.
Fen-phen was voluntarily withdrawn from the market a decade ago, following
reports of life-threatening heart valve disease. Another related diet drug
marketed by Wyeth-Ayerst Laboratories as Redux was also withdrawn.
The diet drugs and their byproducts have been shown by Roth and others to
selectively bind to specific receptors in human heart valve cells, known as
5-HT2B. The same mechanism was seen in the two implicated Parkinson's
"The two new studies provide the best evidence yet for validating this
particular mechanism," Roth tells WebMD. "5-HT2B receptor activity
predicts heart valve disease."
Roth, who is a professor of pharmacology at the University of North Carolina
School of Medicine, Chapel Hill, says all investigational drugs and byproducts
should be screened for 5-HT2B activity in the future.
In an editorial published along with the two studies, Roth called on doctors
to avoid prescribing the drugs.