Parkinson-Plus Syndromes - Topic Overview
Cortical-basal ganglionic degeneration (CBGD)
is a rare neurological disorder that, over time, causes many areas of the brain
to shrink. Initial symptoms may appear on only one side of the body but
eventually affect both sides as the disease progresses. Some symptoms of CBGD
are similar to Parkinson's disease, such as stiff, rigid movements,
tremor, problems with balance and coordination,
difficulty speaking and concentrating, and progressive problems with moving,
thinking, and remembering.
Gradually, problems with understanding
spoken or written language may develop. A phenomenon called "alien limb" can
occur in which the person has trouble controlling the movement of a
Although there is no cure for CBGD, medications are
available to treat its symptoms. Treatment can improve a person's daily
functioning and quality of life.
Dementia with Lewy bodies (DLB)
DLB is a brain
disease that causes progressive changes with movement or thinking. In DLB,
abnormal structures called Lewy bodies form in certain areas of the brain.
Sometimes the symptoms of DLB resemble those of Parkinson’s disease—such as a
shuffling gait, tremor, and problems with movement. In other cases, symptoms
of DLB (such as confusion and memory loss) may mimic the symptoms of
Alzheimer’s disease. Often a combination of both
Parkinson’s and Alzheimer’s symptoms appear together. These symptoms may occur
in DLB because the structures in the brain affected by DLB are similar to those
affected by Parkinson’s disease or Alzheimer’s disease. Some experts think that
DLB may be a form of Parkinson’s disease or Alzheimer’s disease.
The progression of DLB is slow. Although there is no cure for DLB, treatment is
available to reduce symptoms of the disease.