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Parkinson-Plus Syndromes - Topic Overview

Cortical-basal ganglionic degeneration (CBGD)

CBGD is a rare neurological disorder that, over time, causes many areas of the brain to shrink. Initial symptoms may appear on only one side of the body but eventually affect both sides as the disease progresses. Some symptoms of CBGD are similar to Parkinson's disease, such as stiff, rigid movements, tremor, problems with balance and coordination, difficulty speaking and concentrating, and progressive problems with moving, thinking, and remembering.

Gradually, problems with understanding spoken or written language may develop. A phenomenon called "alien limb" can occur in which the person has trouble controlling the movement of a limb.

Although there is no cure for CBGD, medications are available to treat its symptoms. Treatment can improve a person's daily functioning and quality of life.

Dementia with Lewy bodies (DLB)

DLB is a brain disease that causes progressive changes with movement or thinking. In DLB, abnormal structures called Lewy bodies form in certain areas of the brain. Sometimes the symptoms of DLB resemble those of Parkinson’s disease—such as a shuffling gait, tremor, and problems with movement. In other cases, symptoms of DLB (such as confusion and memory loss) may mimic the symptoms of Alzheimer’s disease. Often a combination of both Parkinson’s and Alzheimer’s symptoms appear together. These symptoms may occur in DLB because the structures in the brain affected by DLB are similar to those affected by Parkinson’s disease or Alzheimer’s disease. Some experts think that DLB may be a form of Parkinson’s disease or Alzheimer’s disease.

The progression of DLB is slow. Although there is no cure for DLB, treatment is available to reduce symptoms of the disease.

This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

WebMD Medical Reference from Healthwise

Last Updated: March 12, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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