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    Opening up to your healthcare professional about Peyronie's disease

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    Ask your healthcare professional (HCP) about XIAFLEX®, the only FDA-approved, nonsurgical treatment option for men with Peyronie's disease with a "plaque" that can be felt and a curve in their penis greater than 30 degrees at the start of therapy.

    What Is Peyronie's Disease and How May XIAFLEX® Help Appropriate Patients?

    LEARN MORE

    Talking about Peyronie's disease may not be easy. Your HCP may be able to help

    You may feel embarrassed about discussing a curved erection with your HCP. But remember, your HCP is familiar with this condition, which could be Peyronie's disease.

    If your HCP says you do have Peyronie's disease and a plaque that can be felt, then ask if XIAFLEX® could be right for you.

    Who administers XIAFLEX®?

    XIAFLEX® should only be administered by an HCP experienced in the treatment of urological diseases and who has completed required training for the use of XIAFLEX® to treat Peyronie's disease. Your HCP or urologist may have to refer you to a specialist who meets these qualifications.

    Here are suggested questions you may want to discuss:

    Download this helpful discussion guide for your appointment
    1. Why do I have a curved erection?
      • Is it Peyronie's disease?
    2. If I have Peyronie's disease, is XIAFLEX® right for me?
      • Is the curve of my erection greater than 30 degrees?
      • Do I have a plaque that can be felt?
      • Does the plaque involve the urethra (the tube in the penis that urine flows through)?
        • Do not receive XIAFLEX® if you have been told by your HCP that the Peyronie's plaque to be treated involves the "tube" that your urine passes through (urethra)
    3. What are the possible side effects?
    4. Are there other FDA-approved treatments for Peyronie's disease?
    5. What is involved in treatment with XIAFLEX®?
    6. Are you trained to administer XIAFLEX®? If not, can you refer me to someone who is?

    IMPORTANT SAFETY INFORMATION FOR XIAFLEX®

    Do not receive XIAFLEX® if you:

    • have been told by your healthcare provider that the Peyronie's plaque to be treated involves the "tube" that your urine passes through (urethra)
    • are allergic to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX®, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX®

    XIAFLEX® can cause serious side effects, including:

    1. Penile fracture (corporal rupture) or other serious injury to the penis. Receiving an injection of XIAFLEX® may cause damage to the tubes in your penis called the corpora. After treatment with XIAFLEX®, one of these tubes may break during an erection. This is called a corporal rupture or penile fracture. This could require surgery to fix the damaged area. Damage to your penis might not get better after a corporal rupture.

      • After treatment with XIAFLEX®, blood vessels in your penis may also break, causing blood to collect under the skin (hematoma). This could require a procedure to drain the blood from under the skin

      Symptoms of corporal rupture or other serious injury to your penis may include:

      • a popping sound or sensation in an erect penis
      • sudden loss of the ability to maintain an erection
      • pain in your penis
      • purple bruising and swelling of your penis
      • difficulty urinating or blood in the urine

      Call your healthcare provider right away if you have any of the symptoms of corporal rupture or serious injury to the penis listed above.

      Do not have sex or any other sexual activity between the first and second injections of a treatment cycle.

      Do not have sex or have any other sexual activity for at least 2 weeks after the second injection of a treatment cycle with XIAFLEX® and after any pain and swelling has gone away.

      XIAFLEX® for the treatment of Peyronie's disease is only available through a restricted program called the XIAFLEX® Risk Evaluation and Mitigation Strategy (REMS) Program. For more information about the XIAFLEX® REMS Program, go to www.XIAFLEXREMS.com or call 1‑877‑942‑3539.

    2. Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX®, because it contains foreign proteins.

      Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX®:

      • hives
      • swollen face
      • breathing trouble
      • chest pain
      • low blood pressure
      • dizziness or fainting

    Before receiving XIAFLEX®, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX® injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non‑prescription medicines, vitamins, and herbal supplements. Using XIAFLEX® with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX® injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.

    XIAFLEX® can cause serious side effects, including increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX®. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX® may not be right for you.

    The most common side effects with XIAFLEX® for the treatment of Peyronie's disease include:

    • a small collection of blood under the skin at the injection site (hematoma)
    • swelling at the injection site or along your penis
    • pain or tenderness at the injection site, along your penis and above your penis
    • penis bruising
    • itching of your penis or scrotum (genitals)
    • painful erection
    • erection problems (erectile dysfunction)
    • changes in the color of the skin of your penis
    • blisters at the injection site
    • pain with sex
    • a lump at the injection site (nodule)

    Tell your healthcare provider if you have any side effect that bothers you or does not go away.

    These are not all of the possible side effects with XIAFLEX®. For more information, ask your healthcare provider or pharmacist.

    WHAT IS XIAFLEX®?

    XIAFLEX® is a prescription medicine used to treat adult men with Peyronie's disease who have a "plaque" that can be felt and a curve in their penis greater than 30 degrees when treatment is started.

    It is not known if XIAFLEX® is safe and effective in children under the age of 18.

    Please see the full Prescribing Information, including Boxed Warning and Medication Guide.

    IMPORTANT SAFETY INFORMATION FOR XIAFLEX®

    Do not receive XIAFLEX® if you:

    • have been told by your healthcare provider that the Peyronie's plaque to be treated involves the "tube" that your urine passes through (urethra)
    • are allergic to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX®, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX®

    XIAFLEX® can cause serious side effects, including:

    1. Penile fracture (corporal rupture) or other serious injury to the penis. Receiving an injection of XIAFLEX® may cause damage to the tubes in your penis called the corpora. After treatment with XIAFLEX®, one of these tubes may break during an erection. This is called a corporal rupture or penile fracture. This could require surgery to fix the damaged area. Damage to your penis might not get better after a corporal rupture.

      • After treatment with XIAFLEX®, blood vessels in your penis may also break, causing blood to collect under the skin (hematoma). This could require a procedure to drain the blood from under the skin

      Symptoms of corporal rupture or other serious injury to your penis may include:

      • a popping sound or sensation in an erect penis
      • sudden loss of the ability to maintain an erection
      • pain in your penis
      • purple bruising and swelling of your penis
      • difficulty urinating or blood in the urine

      Call your healthcare provider right away if you have any of the symptoms of corporal rupture or serious injury to the penis listed above.

      Do not have sex or any other sexual activity between the first and second injections of a treatment cycle.

      Do not have sex or have any other sexual activity for at least 2 weeks after the second injection of a treatment cycle with XIAFLEX® and after any pain and swelling has gone away.

      XIAFLEX® for the treatment of Peyronie's disease is only available through a restricted program called the XIAFLEX® Risk Evaluation and Mitigation Strategy (REMS) Program. For more information about the XIAFLEX® REMS Program, go to www.XIAFLEXREMS.com or call 1‑877‑942‑3539.

    2. Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX®, because it contains foreign proteins.

      Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX®:

      • hives
      • swollen face
      • breathing trouble
      • chest pain
      • low blood pressure
      • dizziness or fainting

    Before receiving XIAFLEX®, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX® injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non‑prescription medicines, vitamins, and herbal supplements. Using XIAFLEX® with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX® injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.

    XIAFLEX® can cause serious side effects, including increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX®. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX® may not be right for you.

    The most common side effects with XIAFLEX® for the treatment of Peyronie's disease include:

    • a small collection of blood under the skin at the injection site (hematoma)
    • swelling at the injection site or along your penis
    • pain or tenderness at the injection site, along your penis and above your penis
    • penis bruising
    • itching of your penis or scrotum (genitals)
    • painful erection
    • erection problems (erectile dysfunction)
    • changes in the color of the skin of your penis
    • blisters at the injection site
    • pain with sex
    • a lump at the injection site (nodule)

    Tell your healthcare provider if you have any side effect that bothers you or does not go away.

    These are not all of the possible side effects with XIAFLEX®. For more information, ask your healthcare provider or pharmacist.

    Please see the full Prescribing Information, including Boxed Warning and Medication Guide.