What is Peyronie's disease?
Peyronie's (pronounced "Pay-ROH-neez") disease is caused by a plaque under the skin of the penis that results in a bent, or curved penis when erect. A Peyronie's plaque may result from injury to the penis and/or genetic factors; however, the exact cause of Peyronie's disease is unknown.
Peyronie's disease is unlikely to go away on its own, and may get worse over time. That's why speaking to your HCP about it is so important.
XIAFLEX® is the only FDA-approved treatment for appropriate patients with Peyronie's disease
XIAFLEX® is the only treatment approved by the FDA to help treat Peyronie's disease in adult men who have a "plaque" that can be felt and a curve in their penis greater than 30 degrees when treatment is started.
Prescription XIAFLEX® is injected into the scar tissue or Peyronie's plaque. XIAFLEX® works to help weaken and break down the plaque. This along with gentle stretching and straightening activities, can help to straighten the curve in the erect penis caused by Peyronie's disease.
Results from 2 large clinical studies for XIAFLEX®
Men received either up to 4 treatment cycles of XIAFLEX® with penile modeling, or placebo injection with penile modeling*, and then were observed until 52 weeks.
The goal of 2 large clinical studies involving more than 500 patients was to:
- Measure the change in erectile curvature from the beginning of the study to Week 52
- Measure the change in the Bother domain score from the beginning of the study to Week 52
- Evaluate safety
Improvement in erectile curvature
In the first study, men who received XIAFLEX® and penile modeling had an average change in their erectile curvature from the beginning of the study to Week 52 of 35%, compared with 18% in men who had placebo injection and penile modeling alone.*
In the second study, men who received XIAFLEX® and penile modeling had an average change in their erectile curvature from the beginning of the study to Week 52 of 33%, compared with 22% in men who had placebo injection and penile modeling alone.*
Improvement in bother section scores from the PDQ
Patients in the studies were asked to answer questions from the Bother section of the Peyronie's Disease Questionnaire (PDQ) at the beginning and end (Week 52) of the studies. The bother section score is a total score from answers related to the following:
- Concern about how erection looks
- Concern about erection pain
- Impact of Peyronie's disease on frequency of intercourse
- Impact of Peyronie's disease on intercourse
In the first study, men who received XIAFLEX® and penile modeling had an average reduction in their Bother section scores of 37% from the beginning of the study to Week 52, compared with 22% in men who had placebo injection and penile modeling.*
In the second study, men who received XIAFLEX® and penile modeling had an average reduction in their Bother section scores of 35% from the beginning of the study to Week 52, compared with 18% in men who had placebo injection and penile modeling.*
IMPORTANT SAFETY INFORMATION FOR XIAFLEX®
Do not receive XIAFLEX® if you:
- have been told by your healthcare provider that the Peyronie's plaque to be treated involves the "tube" that your urine passes through (urethra)
- are allergic to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX®, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX®
XIAFLEX® can cause serious side effects, including:
Penile fracture (corporal rupture) or other serious injury to the penis. Receiving an injection of XIAFLEX® may cause damage to the tubes in your penis called the corpora. After treatment with XIAFLEX®, one of these tubes may break during an erection. This is called a corporal rupture or penile fracture. This could require surgery to fix the damaged area. Damage to your penis might not get better after a corporal rupture.
- After treatment with XIAFLEX®, blood vessels in your penis may also break, causing blood to collect under the skin (hematoma). This could require a procedure to drain the blood from under the skin
Symptoms of corporal rupture or other serious injury to your penis may include:
- a popping sound or sensation in an erect penis
- sudden loss of the ability to maintain an erection
- pain in your penis
- purple bruising and swelling of your penis
- difficulty urinating or blood in the urine
Call your healthcare provider right away if you have any of the symptoms of corporal rupture or serious injury to the penis listed above.
Do not have sex or any other sexual activity between the first and second injections of a treatment cycle.
Do not have sex or have any other sexual activity for at least 2 weeks after the second injection of a treatment cycle with XIAFLEX® and after any pain and swelling has gone away.
XIAFLEX® for the treatment of Peyronie's disease is only available through a restricted program called the XIAFLEX® Risk Evaluation and Mitigation Strategy (REMS) Program. For more information about the XIAFLEX® REMS Program, go to www.XIAFLEXREMS.com or call 1‑877‑942‑3539.
Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX®, because it contains foreign proteins.
Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX®:
- swollen face
- breathing trouble
- chest pain
- low blood pressure
- dizziness or fainting
Before receiving XIAFLEX®, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX® injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non‑prescription medicines, vitamins, and herbal supplements. Using XIAFLEX® with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX® injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.
XIAFLEX® can cause serious side effects, including increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX®. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX® may not be right for you.
The most common side effects with XIAFLEX® for the treatment of Peyronie's disease include:
- a small collection of blood under the skin at the injection site (hematoma)
- swelling at the injection site or along your penis
- pain or tenderness at the injection site, along your penis and above your penis
- penis bruising
- itching of your penis or scrotum (genitals)
- painful erection
- erection problems (erectile dysfunction)
- changes in the color of the skin of your penis
- blisters at the injection site
- pain with sex
- a lump at the injection site (nodule)
Tell your healthcare provider if you have any side effect that bothers you or does not go away.
These are not all of the possible side effects with XIAFLEX®. For more information, ask your healthcare provider or pharmacist.
WHAT IS XIAFLEX®?
XIAFLEX® is a prescription medicine used to treat adult men with Peyronie's disease who have a "plaque" that can be felt and a curve in their penis greater than 30 degrees when treatment is started.
It is not known if XIAFLEX® is safe and effective in children under the age of 18.
Please see the full Prescribing Information, including Boxed Warning and Medication Guide.
This product information is intended for U.S. residents only.
XIAFLEX® is a registered trademark of Endo International plc or one of its affiliates.
© 2016 Endo Pharmaceuticals Inc. All rights reserved. Malvern, PA 19355
XP-05018/September 2016 www.xiaflex.com 1-800-462-ENDO (3636)
The information in this website should not take the place of talking with your doctor or healthcare professional.
You are encouraged to report negative side effects of prescription drugs. Contact Endo Pharmaceuticals, at 1‑877‑663‑0412 or the FDA at 1‑800‑FDA‑1088 or www.FDA.gov/medwatch.
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