How ENBREL Works
Plaque psoriasis and psoriatic arthritis are diseases of the immune system. In patients with plaque psoriasis and psoriatic arthritis, certain immune cells are activated and play an important role. They overproduce inflammatory proteins such as tumor necrosis factor (TNF). These proteins can cause inflammation in the skin, which can cause skin cells to grown too quickly. The skin cells build up and form raised, red patches, often with silvery scales, known as psoriatic lesions. These plaques may itch, be painful, and can bleed. This protein also causes inflammation in the joints, which can create pain and progressive joint damage.
Targeting the Source
Biologic therapies like Enbrel® (etanercept) actually target the source of psoriatic skin symptoms and can help lessen the joint pain and help stop joint damage associated with psoriatic arthritis. ENBREL blocks the activity of excess TNF to reduce the inflammation that causes psoriatic lesions and joint pain. Because ENBREL works on your immune system, it may lower the ability of your immune system to fight infections and may raise other safety concerns. If you have any sign of an infection including a fever, cough, flu-like symptoms, or have any open sores on your body, call your doctor. Please see Prescribing Information, Important Safety Information, and Medication Guide for complete details about ENBREL.