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Medical Reference Related to Prostate Cancer

  1. Prostate Cancer, Advanced or Metastatic - Changes to This Summary (10 / 10 / 2014)

    The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.LycopeneAdded text about a 2013 meta-analysis, including four of five cohort studies from a 2004 meta-analysis, two new meta-analyses, and three case-control studies from the previous study plus eight new ones, that reported less convincing evidence for risk reduction; the authors concluded that tomatoes may play a modest role in the prevention of prostate cancer (cited Chen et al. as reference 26).SoyAdded text about an updated 2013 meta-analysis that confirmed the good safety profiles of isoflavones but indicated no significant differences between treated and control groups for prostate-specific antigen (PSA) levels or sex steroid endpoints (cited van Die et al. as reference 22).Added text to state that another group conducted a randomized placebo-controlled trial to examine the effect of soy

  2. Hormone Therapy for Prostate Cancer (Androgen Deprivation Therapy, or ADT) - Genes With Potential Clinical Relevance in Prostate Cancer Risk

    While genetic testing for prostate cancer is not yet standard clinical practice, research from selected cohorts has reported that prostate cancer risk is elevated in men with mutations in BRCA1, BRCA2, and on a smaller scale, in mismatch repair (MMR) genes. Since clinical genetic testing is available for these genes, information about risk of prostate cancer based on alterations in these genes is included in this section. In addition, mutations in HOXB13 were reported to account for a proportion of hereditary prostate cancer. Although clinical testing is not yet available for HOXB13 alterations, it is expected that this gene will have clinical relevance in the future and therefore it is also included in this section. The genetic alterations described in this section require further study and are not to be used

  3. Prostate Cancer, Advanced or Metastatic - Pomegranate

    OverviewThis section contains the following key information:The pomegranate (Punica granatum L.) is native to Asia and cultivated widely throughout world.Various components of the pomegranate fruit contain bioactive compounds, including catechin phenolics, related flavonoids, and anthocyanins, some of which have antioxidant activity.Pomegranate juice and extract, as well as some of their bioactive components, inhibit the proliferation of various prostate cancer cell lines in vitro and induce apoptotic cell death in a dose-dependent manner.Cytochrome P450 enzyme inhibition and effects on insulin-like growth factor binding protein -3 (IGFBP-3) have been identified as being involved in the in vitro anticancer activity.Studies in rodent models of prostate cancer have shown that ingestion of pomegranate juice can decrease the rate of development, growth, and spread of prostate cancer.The only fully reported clinical trial of the use of pomegranate juice in men with prostate

  4. Prostate Cancer, Advanced or Metastatic - Stage IV Prostate Cancer Treatment

    OverviewStage IV prostate cancer is defined by the American Joint Committee on Cancer's TNM classification system:[1]T4, N0, M0, any prostate-specific antigen (PSA), any Gleason.Any T, N1, M0, any PSA, any Gleason.Any T, any N, M1, any PSA, any Gleason.Extraprostatic extension with microscopic bladder neck invasion (T4) is included with T3a.Treatment selection depends on the following factors:Age.Coexisting medical illnesses.Symptoms.The presence of distant metastases (most often bone) or regional lymph node involvement only.The most common symptoms originate from the urinary tract or from bone metastases. Palliation of symptoms from the urinary tract with transurethral resection of the prostate (TURP) or radiation therapy and palliation of symptoms from bone metastases with radiation therapy or hormonal therapy are an important part of the management of these patients. Bisphosphonates may also be used for the management of bone

  5. Hormone Therapy for Prostate Cancer (Androgen Deprivation Therapy, or ADT) - About This PDQ Summary

    Purpose of This SummaryThis PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about prostate cancer. It is intended as a resource to inform and assist clinicians who care for cancer patients. It does not provide formal guidelines or recommendations for making health care decisions.Reviewers and UpdatesThis summary is reviewed regularly and updated as necessary by the PDQ Cancer Complementary and Alternative Medicine Editorial Board, which is editorially independent of the National Cancer Institute (NCI). The summary reflects an independent review of the literature and does not represent a policy statement of NCI or the National Institutes of Health (NIH). Board members review recently published articles each month to determine whether an article should:be discussed at a meeting,be cited with text, orreplace or update an existing article that is already cited.Changes to the summaries are made through a consensus

  6. Prostate Cancer, Advanced or Metastatic - Risks of Prostate Cancer Screening

    Screening tests have risks.Decisions about screening tests can be difficult. Not all screening tests are helpful and most have risks. Before having any screening test, you may want to discuss the test with your doctor. It is important to know the risks of the test and whether it has been proven to reduce the risk of dying from cancer.The risks of prostate screening include the following:Finding prostate cancer may not improve health or help a man live longer.Screening may not improve your health or help you live longer if you have cancer that has already spread to the area outside of the prostate or to other places in your body. Some cancers never cause symptoms or become life-threatening, but if found by a screening test, the cancer may be treated. Finding these cancers is called overdiagnosis. It is not known if treatment of these cancers would help you live longer than if no treatment were given, and treatments for cancer, such as surgery and radiation therapy, may have serious

  7. Prostate Cancer, Advanced or Metastatic - Prostate Cancer Screening

    Tests are used to screen for different types of cancer.Some screening tests are used because they have been shown to be helpful both in finding cancers early and decreasing the chance of dying from these cancers. Other tests are used because they have been shown to find cancer in some people; however, it has not been proven in clinical trials that use of these tests will decrease the risk of dying from cancer. Scientists study screening tests to find those with the fewest risks and most benefits. Cancer screening trials also are meant to show whether early detection (finding cancer before it causes symptoms) decreases a person's chance of dying from the disease. For some types of cancer, finding and treating the disease at an early stage may result in a better chance of recovery.There is no standard or routine screening test for prostate cancer.Screening tests for prostate cancer are under study, and there are screening clinical trials taking place in many parts of the country.

  8. Prostate Cancer, Advanced or Metastatic - nci_ncicdr0000062853-nci-header

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER.Prostate Cancer Prevention

  9. Prostate Cancer, Advanced or Metastatic - To Learn More About Prostate Cancer

    For more information from the National Cancer Institute about prostate cancer, see the following:Prostate Cancer Home PageWhat You Need to Know About™ Prostate CancerProstate Cancer PreventionProstate Cancer ScreeningDrugs Approved for Prostate CancerProstate-Specific Antigen (PSA) TestTreatment Choices for Men with Early-Stage Prostate CancerCryosurgery in Cancer Treatment: Questions and AnswersFor general cancer information and other resources from the National Cancer Institute, see the following:What You Need to Know About™ CancerUnderstanding Cancer Series: CancerCancer StagingChemotherapy and You: Support for People With CancerRadiation Therapy and You: Support for People With CancerCoping with Cancer: Supportive and Palliative CareQuestions to Ask Your Doctor About CancerCancer LibraryInformation For Survivors/Caregivers/Advocates

  10. Prostate Cancer, Advanced or Metastatic - Questions and Answers About Soy

    What is Zyflamend?Zyflamend is a dietary supplement that contains 10 different herbs. Zyflamend contains extracts of rosemary, turmeric, ginger, holy basil, green tea, hu zhang (Polygonum cuspidatum, a source of resveratrol), Chinese goldthread, barberry, oregano, and Baikal skullcap.The extracts found in Zyflamend have anti-inflammatory activity and possible anticancer benefits. There is limited evidence about how Zyflamend may act against tumor growth. Zyflamend has been shown to interfere with the activity of COX-1 and COX-2 enzymes, which are involved in the development of inflammation and possibly cancer. Zyflamend may also act against the NF-kappa B and lipoxygenase (LOX) families of proteins that stimulate tumor growth. How is Zyflamend administered or consumed?Zyflamend is taken as a dietary supplement in capsule form. Have any preclinical (laboratory or animal) studies been conducted using Zyflamend?Laboratory and animal research has recently been done to study the effects of

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