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Medical Reference Related to Prostate Cancer

  1. Questions and Answers About Zyflamend

    What is Zyflamend?Zyflamend is a dietary supplement that contains 10 different herbs. Zyflamend contains extracts of rosemary, turmeric, ginger, holy basil, green tea, hu zhang (Polygonum cuspidatum, a source of resveratrol), Chinese goldthread, barberry, oregano, and Baikal skullcap.The extracts found in Zyflamend have anti-inflammatory activity and possible anticancer benefits. There is limited evidence about how Zyflamend may act against tumor growth. Zyflamend has been shown to interfere with the activity of COX-1 and COX-2 enzymes, which are involved in the development of inflammation and possibly cancer. Zyflamend may also act against the NF-kappa B and lipoxygenase (LOX) families of proteins that stimulate tumor growth. How is Zyflamend administered or consumed?Zyflamend is taken as a dietary supplement in capsule form. Have any preclinical (laboratory or animal) studies been conducted using Zyflamend?Laboratory and animal research has recently been done to study the effects of

  2. Pomegranate

    OverviewThis section contains the following key information:The pomegranate (Punica granatum L.) is native to Asia and cultivated widely throughout world.Various components of the pomegranate fruit contain bioactive compounds, including phenolics, flavonoids, and anthocyanins, some of which have antioxidant activity.Pomegranate juice and extract, as well as some of their bioactive components, inhibit the proliferation of various prostate cancer cell lines in vitro and induce apoptotic cell death in a dose-dependent manner.Cytochrome P450 enzyme inhibition and effects on insulin-like growth factor binding protein -3 (IGFBP-3) have been identified as being involved in the in vitro anticancer activity.Studies in rodent models of prostate cancer have shown that ingestion of pomegranate juice can decrease the rate of development, growth, and spread of prostate cancer.The only fully reported clinical trial of the use of pomegranate juice in men with prostate cancer showed that,

  3. Prostate Cancer Prevention

    The prostate is a gland in males that is involved in the production of semen. It is located between the bladder and the rectum. The normal prostate gland is the size of a walnut and surrounds the urethra,the tube that carries urine from the bladder. Significance of prostate cancer Prostate cancer is the most common nonskin cancer among men in the United States. Although the number of men ...

  4. Get More Information From NCI

    National Cancer Institute for more cancer information.

  5. Opportunities for Prevention

    Hormonal Prevention The Prostate Cancer Prevention Trial (PCPT),a large randomized placebo-controlled trial of finasteride (an inhibitor of alpha-reductase),was performed in 18,882 men aged 55 years or older. At 7 years,the incidence of prostate cancer was 18.4% in the finasteride group versus 24.4% in the placebo group,a relative risk reduction of 24.8% (95% confidence interval [CI],...

  6. Questions or Comments About This Summary

    If you have questions or comments about this summary,please send them to Cancer.gov through the Web site’s Contact Form. We can respond only to email messages written in English. ...

  7. Stage IV Prostate Cancer Treatment

    OverviewStage IV prostate cancer is defined by the American Joint Committee on Cancer's TNM classification system:[1]T4, N0, M0, any prostate-specific antigen (PSA), any Gleason.Any T, N1, M0, any PSA, any Gleason.Any T, any N, M1, any PSA, any Gleason.Extraprostatic extension with microscopic bladder neck invasion (T4) is included with T3a.Treatment selection depends on the following factors:Age.Coexisting medical illnesses.Symptoms.The presence of distant metastases (most often bone) or regional lymph node involvement only.The most common symptoms originate from the urinary tract or from bone metastases. Palliation of symptoms from the urinary tract with transurethral resection of the prostate (TURP) or radiation therapy and palliation of symptoms from bone metastases with radiation therapy or hormonal therapy are an important part of the management of these patients. Bisphosphonates may also be used for the management of bone

  8. About PDQ

    PDQ IS A COMPREHENSIVE CANCER DATABASE AVAILABLE ON NCI'S WEB SITE. PDQ is the National Cancer Institute's (NCI's) comprehensive cancer information database. Most of the information contained in PDQ is available online at NCI's Web site. PDQ is provided as a service of the NCI. The NCI is part of the National Institutes of Health,the federal government's focal point for biomedical research. .

  9. Questions or Comments About This Summary

    If you have questions or comments about this summary,please send them to Cancer.gov through the Web site’s Contact Form. We can respond only to email messages written in English. ...

  10. Soy

    OverviewThis section contains the following key information:Soy foods (e.g., soy milk, miso, tofu, and soy flour) contain phytochemicals that may have health benefits and, among these, soy isoflavones have been the focus of most of the research.Soy isoflavones are phytoestrogens. The major isoflavones in soybeans are genistein (the most abundant), daidzein, and glycitein.Genistein affects components of multiple growth and proliferation -related pathways in prostate cancer cells, including the COX-2 /prostaglandin, epidermal growth factor (EGF), and insulin-like growth factor (IGF) pathways.Some preclinical studies have indicated that the combined effect of multiple isoflavones may be greater than that of a single isoflavone.Some animal studies have demonstrated prostate cancer prevention effects with soy and genistein; however, other animal studies have yielded conflicting results regarding beneficial effects of genistein on prostate cancer metastasis.Epidemiologic studies have

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