OverviewThis section contains the following key information:The pomegranate (Punica granatum L.) is native to Asia and cultivated widely throughout world.Various components of the pomegranate fruit contain bioactive compounds, including phenolics, flavonoids, and anthocyanins, some of which have antioxidant activity.Pomegranate juice and extract, as well as some of their bioactive components, inhibit the proliferation of various prostate cancer cell lines in vitro and induce apoptotic cell death in a dose-dependent manner.Cytochrome P450 enzyme inhibition and effects on insulin-like growth factor binding protein -3 (IGFBP-3) have been identified as being involved in the in vitro anticancer activity.Studies in rodent models of prostate cancer have shown that ingestion of pomegranate juice can decrease the rate of development, growth, and spread of prostate cancer.The only fully reported clinical trial of the use of pomegranate juice in men with prostate cancer showed that,
Questions and Answers About Soy
What is soy?The soybean plant has been grown in Asia for food since ancient times. Soy first arrived in Europe and North America in the 18th century. The soybean can be processed into a wide variety of products including soy milk, miso, tofu, soy flour, and oil. Soy foods contain many phytochemicals that may have health benefits. Isoflavones are the most widely researched compounds in soy. Major isoflavones in the soybean include genistein (which may be the most bioactive isoflavone), daidzein, and glycitein. Isoflavones protect the soybean plant from stress and have antioxidant, antimicrobial, and antifungal actions.Isoflavones are phytoestrogens (estrogen -like substances found in plants) that attach to estrogen receptors in cells. Genistein has been shown to affect many pathways in prostate cancer cells involved in the growth and spread of cancer. How is soy administered or consumed? Soy may be consumed in the diet or taken in dietary supplements. Have any preclinical (laboratory
Evidence of Benefit
Prior to the 1990s,the digital rectal examination (DRE) was the test traditionally mentioned for prostate cancer screening. Two other test procedures are also available: transrectal ultrasound (TRUS) imaging and serum prostate-specific antigen (PSA) concentrations.[ 1 ] Prostate cancer screening is controversial because of the lack of definitive evidence of benefit. A small randomized trial in .
Prostate Cancer Prevention
The prostate is a gland in males that is involved in the production of semen. It is located between the bladder and the rectum. The normal prostate gland is the size of a walnut and surrounds the urethra,the tube that carries urine from the bladder. Significance of prostate cancer Prostate cancer is the most common nonskin cancer among men in the United States. Although the number of men ...
Recurrent Prostate Cancer Treatment
OverviewIn recurrent prostate cancer, the selection of further treatment depends on many factors, including:Previous treatment.Site of recurrence.Coexistent illnesses.Individual patient considerations. Definitive radiation therapy can be given to patients with disease that fails only locally following prostatectomy.[1,2,3,4] An occasional patient can be salvaged with prostatectomy after a local recurrence following definitive radiation therapy; however, only about 10% of patients treated initially with radiation therapy will have local relapse only. In these patients, prolonged disease control is often possible with hormonal therapy, with median cancer-specific survival of 6 years after local failure.Cryosurgical ablation of recurrence following radiation therapy is associated frequently with a high complication rate. This technique is still undergoing clinical evaluation.Hormonal therapy is used to manage most relapsing patients with disseminated
Questions or Comments About This Summary
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Overview of CAM Use in Prostate Cancer
Studies of CAM use to treat prostate cancer have shown the following:Men who have prostate cancer are more likely to take dietary supplements than men who do not have prostate cancer.Prostate cancer patients with the healthiest eating habits (for example, eating lots of fish rich in omega-3 fatty acids and vegetables) are the most likely to take dietary supplements.Popular dietary supplements used by prostate cancer patients include lycopene, vitamin E, selenium, and saw palmetto.Reasons given by prostate cancer patients for using CAM treatments include boosting the immune system, improving quality of life, and lowering the risk of the cancer coming back.Studies of CAM use to lower the risk of developing prostate cancer or to prevent it from coming back have shown the following:A study of men with a family history of prostate cancer found that over half used vitamins or other dietary supplements, including those sold for prostate health or cancer prevention such as selenium, green
Questions and Answers About Modified Citrus Pectin
What is modified citrus pectin?Pectin is a type of polysaccharide (a carbohydrate with many small sugar molecules that are chemically linked). Pectin is found in the cell walls of most plants and has gel-like qualities that are useful in making many types of food and medicine.Citrus pectin is found in the peel and pulp of citrus fruits such as oranges, grapefruit, lemons, and limes. Citrus pectin can be modified with high pH and heat to break its molecules into smaller pieces. Modified citrus pectin (also called MCP) can be digested and absorbed by the body. How is MCP administered or consumed? MCP may be taken by mouth in powder or capsule form. Have any preclinical (laboratory or animal) studies been conducted using MCP? A study in prostate cancer cells compared 3 different kinds of pectin: citrus pectin, PectaSol (a dietary supplement with MCP), and fractionated pectin powder. Prostate cancer cells treated with the pectin powder had more damage than those treated with citrus pectin
Changes to This Summary (02 / 15 / 2013)
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.SignificanceUpdated statistics with estimated new cases and deaths for 2013 (cited American Cancer Society as reference 1).This summary is written and maintained by the PDQ Screening and Prevention Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.
Treatment Option Overview for Prostate Cancer
Local treatment modalities are associated with prolonged disease-free survival for many patients with localized prostate cancer but are rarely curative in patients with locally extensive tumors. Because of clinical understaging using current diagnostic techniques, even when the cancer appears clinically localized to the prostate gland, some patients develop disseminated tumors after local therapy with surgery or radiation. Metastatic prostate cancer is currently not curable.Treatment options for each stage of prostate cancer are presented in Table 9.Table 9. Treatment Options by Stage for Prostate CancerStage (TNM Staging Criteria)Standard Treatment OptionsTURP = transurethral resection of the prostate.Stage I Prostate CancerWatchful waiting or active surveillanceRadical prostatectomyExternal-beam radiation therapy (EBRT)Interstitial implantation of radioisotopesStage II Prostate CancerWatchful waiting or active