Prostate Cancer, Advanced or Metastatic - Pomegranate
OverviewThis section contains the following key information:The pomegranate (Punica granatum L.) is native to Asia and cultivated widely throughout world.Various components of the pomegranate fruit contain bioactive compounds, including catechin phenolics, related flavonoids, and anthocyanins, some of which have antioxidant activity.Pomegranate juice and extract, as well as some of their bioactive components, inhibit the proliferation of various prostate cancer cell lines in vitro and induce apoptotic cell death in a dose-dependent manner.Cytochrome P450 enzyme inhibition and effects on insulin-like growth factor binding protein -3 (IGFBP-3) have been identified as being involved in the in vitro anticancer activity.Studies in rodent models of prostate cancer have shown that ingestion of pomegranate juice can decrease the rate of development, growth, and spread of prostate cancer.The only fully reported clinical trial of the use of pomegranate juice in men with prostate
Prostate Cancer, Nutrition, and Dietary Supplements (PDQ®): Complementary and alternative medicine - Patient Information [NCI] - Questions and Answers About Vitamin D
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above. Changes were made to this summary to match those made to the health professional version.
Prostate Cancer, Advanced or Metastatic - About This PDQ Summary
About PDQPhysician Data Query (PDQ) is the National Cancer Institute's (NCI's) comprehensive cancer information database. The PDQ database contains summaries of the latest published information on cancer prevention, detection, genetics, treatment, supportive care, and complementary and alternative medicine. Most summaries come in two versions. The health professional versions have detailed information written in technical language. The patient versions are written in easy-to-understand, nontechnical language. Both versions have cancer information that is accurate and up to date and most versions are also available in Spanish.PDQ is a service of the NCI. The NCI is part of the National Institutes of Health (NIH). NIH is the federal government's center of biomedical research. The PDQ summaries are based on an independent review of the medical literature. They are not policy statements of the NCI or the NIH.Purpose of This SummaryThis PDQ cancer information summary has current
Prostate Cancer, Advanced or Metastatic - What is prevention?
WebMD discusses methods of preventing prostate cancer.
Prostate Cancer, Advanced or Metastatic - Zyflamend
OverviewZyflamend is a dietary supplement that contains extracts of rosemary, turmeric, ginger, holy basil, green tea, hu zhang, Chinese goldthread, barberry, oregano, and Baikal skullcap.The individual components of Zyflamend have anti-inflammatory and possible anticarcinogenic properties.In various preclinical studies, Zyflamend has been shown to suppress the expression of certain genes involved in the inflammatory response and in cancer progression, such as cyclooxygenase 1(COX-1), COX-2, 5-lipoxygenase (5-LOX), and 12-LOX.In other preclinical studies, Zyflamend has demonstrated single-agent anticancer activity and the capacity to be used with hormonal and chemotherapy agents for improved cancer suppression.Results of a phase I study of Zyflamend suggest that use of this supplement is not associated with serious toxicity or adverse effects.General Information and HistoryZyflamend is a dietary supplement that contains extracts of rosemary (Rosmarinus officinalis L.),
Prostate Cancer, Nutrition, and Dietary Supplements (PDQ®): Complementary and alternative medicine - Patient Information [NCI] - Evaluation of CAM Approaches
It is important that the same rigorous scientific evaluation used to assess conventional approaches be used to evaluate CAM therapies. The National Cancer Institute (NCI) and the National Center for Complementary and Alternative Medicine (NCCAM) are sponsoring a number of clinical trials (research studies) at medical centers to evaluate CAM therapies for cancer. Conventional approaches to cancer treatment have generally been studied for safety and effectiveness through a rigorous scientific process that includes clinical trials with large numbers of patients. Less is known about the safety and effectiveness of complementary and alternative methods. Few CAM therapies have undergone rigorous evaluation. A small number of CAM therapies originally considered to be purely alternative approaches are finding a place in cancer treatment—not as cures, but as complementary therapies that may help patients feel better and recover faster. One example is acupuncture. According to a panel of
Prostate Cancer, Nutrition, and Dietary Supplements (PDQ®): Complementary and alternative medicine - Health Professional Information [NCI] - Stage II Prostate Cancer Treatment
OverviewStage II prostate cancer is defined by the American Joint Committee on Cancer's TNM classification system:Stage IIAT1a–c, N0, M0, prostate-specific antigen (PSA) <20 ng/ml, Gleason 7.T1a–c, N0, M0, PSA ≥10 <20 ng/ml, Gleason ≤6.T2a, N0, M0, PSA ≥10 <20 ng/ml, Gleason ≤6.T2a, N0, M0, PSA <20 ng/ml, Gleason 7.T2b, N0, M0, PSA <20 ng/ml, Gleason ≤7.T2b, N0, M0, PSA X, Gleason X.Stage IIBT2c, N0, M0, any PSA, any Gleason.T1–2, N0, M0, PSA ≥20 ng/ml, any Gleason.T1–2, N0, M0, any PSA, Gleason ≥8.Radical prostatectomy, external-beam radiation therapy (EBRT), and interstitial implantation of radioisotopes are each employed in the treatment of stage II prostate cancer with apparently similar therapeutic effects. Radical prostatectomy and radiation therapy yield apparently similar survival rates with as many as 10 years of follow-up. For well-selected patients, radical prostatectomy
Prostate Cancer, Advanced or Metastatic - Questions and Answers About Soy
What is Zyflamend?Zyflamend is a dietary supplement that contains 10 different herbs. Zyflamend contains extracts of rosemary, turmeric, ginger, holy basil, green tea, hu zhang (Polygonum cuspidatum, a source of resveratrol), Chinese goldthread, barberry, oregano, and Baikal skullcap.The extracts found in Zyflamend have anti-inflammatory activity and possible anticancer benefits. There is limited evidence about how Zyflamend may act against tumor growth. Zyflamend has been shown to interfere with the activity of COX-1 and COX-2 enzymes, which are involved in the development of inflammation and possibly cancer. Zyflamend may also act against the NF-kappa B and lipoxygenase (LOX) families of proteins that stimulate tumor growth. How is Zyflamend administered or consumed?Zyflamend is taken as a dietary supplement in capsule form. Have any preclinical (laboratory or animal) studies been conducted using Zyflamend?Laboratory and animal research has recently been done to study the effects of
Prostate Cancer, Advanced or Metastatic - Green Tea
OverviewThis section contains the following key information:All tea originates from the Camellia sinensis (L.) Kuntze plant, and the methods by which the leaves are processed determine the type of tea produced. For green tea, the leaves are steamed and dried.Some research suggests that green tea may have a protective effect against cardiovascular disease and against various forms of cancer, including prostate cancer.Catechins are polyphenol compounds in tea that are associated with many of tea's proposed health benefits.Epigallocatechin gallate (EGCG), the most abundant catechin in tea, acts as an androgen antagonist and can suppress prostate cancer cell proliferation, suppress production of prostate-specific antigen (PSA) by prostate cancer cells, and increase prostate cancer cell death in vitro.Results from one in vitro study showed that prostate cancer cells were less susceptible to radiation -induced apoptosis when exposed to EGCG 30 minutes
Prostate Cancer, Advanced or Metastatic - Overview
Note: Separate PDQ summaries on Prostate Cancer Screening,Prostate Cancer Treatment,and Levels of Evidence for Cancer Screening and Prevention Studies are also available. Benefits From Finasteride and Dutasteride Chemoprevention Based on solid evidence,chemoprevention with finasteride and dutasteride reduces the incidence of prostate cancer,but the evidence is inadequate to determine whether ...