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Long-Term Effects of Prostate Cancer Treatment

Sexual Function Problems or Urinary Incontinence Still Common 5 Years Later
WebMD Health News

May 25, 2005 -- Two new studies show that sexual or urinary function problems are still common five years after prostate cancer treatment.

The studies, presented at the American Urological Association's annual meeting, looked at the long-term effects of prostate cancer surgery or radiation.

Changes After Surgery

The first study included 1,288 men with prostate cancer whose cancer had not spread beyond the prostate. They all had prostate cancer surgery.

Before surgery, 87% said they had no problem with urinary control and 81% said they had erections firm enough for intercourse. Those numbers fell in the months and years after surgery.

Six months after surgery, half of the men said they had occasional urinary leaks after surgery; those numbers didn't change much during the five-year study. Nearly one in four said they had total urinary control, but this improved to 35% at the end of the study. Fewer reported frequent leaks or no urinary control.

Six months after surgery, 89% of the men said their erections weren't firm enough for intercourse and 70% said sexual function was a "moderate

to big problem." After five years, 71% still had erections that were not firm enough for intercourse, say the researchers, who included David F. Penson, MD, MPH, an assistant professor of urology at the University of Washington.

The researchers say Viagra was the most commonly reported erectile aid, with 43% of the men saying they had ever used it. Among Viagra users, 45% said it helped "somewhat" or "a lot." Viagra is manufactured by Pfizer, a WebMD sponsor.

Radiation vs. Surgery

The second study was smaller and took a different approach. Instead of focusing only on prostate cancer surgery, it compared surgery to prostate cancer radiation.

The study included 137 men with prostate cancer who were randomly assigned to one of the treatments. They were followed for two years by researchers including Savino Di Stasi, MD, PhD, of Rome's Tor Vergata University.

Quality-of-life scores dropped significantly for the men in the surgical group in the first month after surgery. But after that, their quality of life rebounded; both group's scores were similar to those before treatment. Quality of life included measures of bowel, urinary, and sexual functions.

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