Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Font Size

Heart Risk From Prostate Therapy

Androgen Deprivation for Prostate Cancer Boosts Heart Deaths
WebMD Health News
Reviewed by Louise Chang, MD

Oct. 9, 2007 - Depriving the body of male sex hormones fights prostate cancer, but it boosts a man's risk of dying of heart disease.

Androgens -- male sex hormones -- make prostate cancers grow faster. Men with prostate cancer may opt to take drugs that block the effects of androgens, or they may remove the source of the hormones, the testicles, via an operation called an orchiectomy.

Because they deprive the tumor of androgens, these treatments are collectively known as androgen deprivation therapy. Androgen deprivation therapy may be offered before other treatments for prostate cancer, especially radiation therapy. It may also be offered after other treatments to prevent or treat recurrent cancer.

There's no doubt androgen deprivation therapy has a benefit. But recently, researchers have uncovered a new risk: heart disease. Studies show increased risk factors for heart disease in men undergoing androgen-deprivation therapy.

Does this mean an actual increase in risk of death from heart disease? Yes, find Henry Tsai, MD, and colleagues.

"We looked at a large population of men with prostate cancer treated with surgery, one or another form of radiation, or cryotherapy. Then we looked at men treated with the same things but also given a short course of androgen deprivation therapy," Tsai tells WebMD. "We found that the men who received androgen deprivation therapy, especially those with surgery as well, had an increased risk of death from cardiovascular disease."

The researchers analyzed their findings according to the patients' age and the primary treatment they received. Among the 3,262 patients who underwent prostate surgery, the 266 men who also received androgen deprivation therapy had a 2.6-fold higher risk of dying from heart disease.

Most of the deaths were in patients aged 65 and older.

"In patients 65 and older with surgery and androgen deprivation therapy, their five-year risk of cardiovascular death was 5.5%. For those who didn't have androgen deprivation therapy, their five-year risk was 2%."

Androgen Deprivation Risk, Androgen Deprivation Benefit

How big is the risk?

"It depends on how you present the information," Tsai says. "It looks like more than a twofold jump in risk, but it is only a 3% difference. It is a significant increase, but in absolute terms it is pretty small."

Today on WebMD

man with doctor
Symptoms, risks, treatments
man coughing
Men shouldn’t ignore
prostate cancer cells
What does this diagnosis mean?
doctor and male patient
Is it worth it?
cancer fighting foods
15 Cancer Symptoms Men Ignore
Prostate Enlarged
Picture Of The Prostate
Prostate Cancer Quiz
screening tests for men
Prostate Cancer Symptoms
Vitamin D