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This article is from the WebMD News Archive
Can Walking Ward Off Bone Loss?
Oct. 29, 2007 (Los Angeles) -- Brisk walking may reverse the severe bone loss associated with a common prostate cancer therapy, curbing the risk of fractures and osteoporosis, researchers report.
In a small study of men undergoing androgen deprivation therapy (ADT) and radiation for prostate cancer, strolling at a rapid pace for 30 minutes five days a week for eight weeks built bone strength.
In contrast, men who didn't exercise lost bone mass, says researcher Paula Chiplis, PhD, RN, a clinical instructor and senior research assistant in the department of nursing at Johns Hopkins Hospital in Baltimore.
"With exercise, prostate cancer patients gained bone density at a time in life when even healthy men are starting to lose bone density. This is really exciting," Jennifer Wenzel, PhD, RN, a researcher at Johns Hopkins who also worked on the study, tells WebMD.
The findings were reported at the American Society for Therapeutic Radiology and Oncology's annual meeting.
Hormone Therapy
Men with localized cancer that is confined to the prostate gland can be treated with radiation therapy along with ADT. Radiation is used to kill the cancer cells. ADT inhibits the production of hormones called androgens that feed cancer cells, slowing tumor growth and improving the odds of survival.
But androgens also help build bone strength, so suppressing them results in a form of "male menopause," which weakens the bones and increases the risk of fractures and osteoporosis, Chiplis says.
Radiation is also thought to weaken bones, although the reasons are less clear, she adds.
Brisk Walking Builds Bones
But exercise can change all that, Chiplis says. In the study, brisk walking led to a 0.49% gain in bone mass in just eight to 10 weeks.
Men who didn't exercise lost 2.21% of their bone mass in the two-month study period; placed in context, healthy men lose between 0.5 to 1% of their bone mass per year, beginning in middle age, she says.
And men undergoing ADT lose 4% to 13% of their bone density annually, Chiplis tells WebMD. "Given these benchmarks, the effect of exercise is huge."
Exercise May Help
The findings grew out of a larger project designed to look at the effects of exercise on fatigue in 70 men with localized prostate cancer undergoing radiation therapy with or without ADT. Half agreed to take brisk 20 to 30 minute walks five days a week during ADT treatment.
Every two weeks, a nurse called all the participants, asking how they were feeling. Those in the exercise group were also urged to hold back or step up their exercises, depending on how they were feeling.
Having a nurse involved probably helped get the men motivated and out of bed, says Phillip M. Devlin, MD, a cancer specialist at Harvard Medical School and a spokesman for ASTRO.
He urges men with prostate cancer to get moving. While the study was small and needs confirmation, "there is no danger in walking and it could possibly be helpful," Devlin tells WebMD.
How fast do you need to walk to reap the benefits? "As briskly as you can and still carry on a conversation," Chiplis says.
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Indication
Uroxatral® (alfuzosin HCl 10 mg extended-release tablets) is an alpha1-blocker for the treatment of the signs and symptoms of BPH.
Important Safety Information
Do not take UROXATRAL if you have liver problems or if you are taking antifungal drugs like ketoconazole or itraconazole, or HIV drugs like ritonavir.
UROXATRAL can cause a sudden drop in blood pressure, especially when starting treatment. This may lead to fainting, dizziness, and lightheadedness. Do not drive, operate machinery, or do any dangerous activity until you know how UROXATRAL will affect you. This is especially important if you already have a problem with low blood pressure or take medicines to treat high blood pressure. There may be an increased risk of low blood pressure and fainting when taking UROXATRAL in combination with blood pressure medication or nitrates, or erectile dysfunction medication.
If considering cataract surgery (clouding of the eyes), tell your eye surgeon that you are currently taking UROXATRAL or have previously been treated with an alpha-blocker.
Before taking UROXATRAL, tell your doctor if you have kidney problems.
Also, tell your doctor if you or any family member(s) have or take medications for a rare heart condition known as congenital prolongation of the QT interval.
BPH and prostate cancer can cause the same symptoms. However, UROXATRAL is not a treatment for prostate cancer.
The most common side effects with UROXATRAL are dizziness, upper respiratory tract infection, headache, and tiredness.
Please see UROXATRAL full prescribing information.
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