Prostate Cancer Gene Test Coming Soon
Test Screens for 5 Genetic Variants and Will Be Available in Months, Researchers Say
WebMD News Archive
Jan. 16, 2008 -- Scientists at Wake Forest University plan to start offering
a new gene test for prostate cancer risk within
The test screens men's blood or saliva samples for five genetic variants
linked to prostate cancer. Once those blood or saliva samples arrive at
the researchers' lab, the test takes about a week.
"The genetic findings in our paper can be used now, and we plan to make
the test available in the next few months," says Jianfeng Xu, MD, DrPH, of
Wake Forest's Center for Human Genomics, in a statement from Wake Forest
Xu's team describes the test in today's advance online edition of The New
England Journal of Medicine.
Prostate Cancer Gene Test
Xu and colleagues identified the five genetic variants based on blood
samples from on more than 4,600 Swedish men, including nearly 2,900 prostate
The goal was to see if those variants could identify the prostate cancer
patients. Each variant, by itself, was so-so at that task. But together, the
variants did a better job.
For instance, prostate cancer patients were up to five times more likely to
have at least four of the variants.
Family history drove those odds higher. Prostate cancer patients with a
family history of prostate cancer were more than nine times as likely to have
at least four variants.
The findings are "further evidence that prostate cancer has complex and
multifactorial origins," writes editorialist Edward Gelmann, MD, of the
Herbert Irving Comprehensive Cancer Center at New York's Columbia
Who Should Get the Prostate Cancer Gene Test?
In the journal, Xu's team cautions that more work is needed "to test the
value of these findings in assessing the risk of prostate cancer in individual
In his statement, Xu explains why the test will be made available
"We plan to offer the test now because we believe that some men and
their physicians will want to take advantage of these findings -- knowing the
test will be refined over time," says Xu.
Xu -- who co-founded Proactive Genomics, the company that will offer the
test -- doesn't yet know which men are the best candidates for the test.