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More Prostate Cancer Genes Found

Scientists Find at Least 11 New Genes Linked to Prostate Cancer
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WebMD Health News
Reviewed by Louise Chang, MD

Feb. 11, 2008 -- The list of prostate cancer genes just got longer.

Scientists report the discovery of at least 11 new prostate cancer genes, including one that affects prostate cancer's aggressiveness.

These aren't the first prostate cancer genes to be found, and they might not be the last. But the findings are part of the puzzle of prostate cancer genetics, the researchers note.

Three international teams of scientists discovered the new prostate cancer genes. They compared DNA from some 24,500 prostate cancer patients and more than 37,800 men without prostate cancer.

Those comparisons linked prostate cancer to variations in the following genes: MSMB, LMTK2, KLK3, CTBP2, JAZF1, CPNE3, IL16, CDH13, EHBP1, NUDT10, and NUDT11. Several other genetic variations also stood out but haven't been mapped to any particular gene.

The researchers don't know exactly what all of those genes do. But they do know that the MSMB gene makes a protein found in semen, and the CTBP2 gene is particularly active in prostate tissue.

The prostate cancer gene studies appear in the advance online edition of Nature Genetics.

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