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Prostate Cancer: Early Surgery or Watchful Waiting?

Study Shows Early Surgery Cuts Deaths From Low-Risk Prostate Cancer
WebMD Health News
Reviewed by Laura J. Martin, MD

May 4, 2011 -- Fifteen-year results from a Swedish study show that early prostate surgery cuts deaths in under-65 men with "low-risk" prostate tumors -- but for today's men, the definition of "low risk" has changed.

The study of 695 men with early prostate cancer assigned half the men to immediate surgery -- prostatectomy -- and half to watchful waiting. The first results, reported in 2002, showed that early surgery improved survival.

In watchful waiting, patients are not treated but monitored closely to see if there is any progression of the disease.

Now, 15 years after the study began, it's clear that men who underwent early surgery cut their risk of death from prostate cancer by 38%.

However, only men under age 65 saw this benefit. Early surgery did not significantly improve survival in men diagnosed with prostate cancer after age 65, notes Anna Bill-Axelson, MD, PhD, lead author of the report in the May 5 issue of the New England Journal of Medicine.

"What we see is that surgery reduces prostate cancer deaths, but that not all patients need to undergo surgery," Bill-Axelson tells WebMD. "It depends on age, on the presence of other medical conditions, on patient preference, and on how the tumor looks. You cannot generalize and say everybody needs to undergo surgery."

The study showed that:

  • Overall, 15 men had to undergo prostate surgery to save one death from prostate cancer. For men under age 65, seven had to be treated to prevent one prostate cancer death.
  • Men whose tumors had broken through the prostate capsule had a much higher risk of death than did those with tumors that remained inside the capsule.
  • 63% of the men assigned to watchful waiting and 40% of the men assigned to prostatectomy needed androgen-deprivation therapy, which has serious side effects that include sexual dysfunction, fatigue, and risk factors for diabetes and heart disease.
  • More men in the watchful waiting group than in the prostate surgery group died from causes other than prostate cancer but with spreading prostate cancer that would likely have been fatal.

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