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Prostate Cancer: The Basics
The prostate is a muscular, walnut-sized gland that surrounds part of the urethra, the tube that transports urine and sperm out of the body. A gland is a group of cells that secretes chemicals that act on or control the activity of other cells or organs.
The prostate is part of the male reproductive system. Its main job is to make seminal fluid, the milky substance that transports sperm.
Sperm is produced in the testicles, which also make the male hormone testosterone. Testosterone stimulates the growth and function of the prostate during puberty, and also makes prostatic fluid for semen.
During sexual climax (orgasm), the muscles of the prostate contract to push semen through the urethra and out the penis. The urethra also carries urine, a waste product made by the kidneys and stored in the bladder. When the penis is erect during sexual intercourse, the flow of urine is blocked from the urethra, allowing only semen to be ejaculated at orgasm.
Where Is the Prostate Located?
The prostate is located directly beneath the bladder and in front of the rectum. Because the first portion of the urethra passes through the prostate, the passage of urine or semen through the urethra can be obstructed if the gland becomes enlarged.
What Is Prostate Cancer?
Prostate cancer is the most common cancer, excluding skin cancers, in American men. It is a malignant tumor of the prostate. In most men, the cancer grows very slowly. In fact, many men with the disease will never know they have the condition. Early prostate cancer is confined to the prostate gland itself. The majority of patients with this type of cancer can live for years with no problems.
Prostate cancer is characterized by both "grade" and "stage." The grade is given to indicate how quickly a cancer is growing -- the higher the grade, the more likely it is that the cancer will grow and spread rapidly. The size and extent of the tumor determine its stage.
What Causes Prostate Cancer?
As with many cancers, the cause of prostate cancer is unknown. But doctors do know it is more common in African American men and men with a family history of the disease. The male sex hormone testosterone also contributes to its growth. Read more about risk factors.
How Many Men Have Prostate Cancer?
The American Cancer Society estimates that about 234,460 men in the U.S. will be diagnosed with prostate cancer this year, and approximately 27,350 will die of the disease. Despite this fact, there is no universally agreed-upon plan for its diagnosis and management. Overall, about one man in six will be diagnosed with prostate cancer during his lifetime, but only one man in 34 will die of this disease. About 80 percent of men who reach age 80 have prostate cancer.
What Is the Outlook?
While the number of men diagnosed with prostate cancer remains high, survival rates are also improving. Nearly 100% of men with prostate cancer survive at least five years after their diagnosis, 93% survive at least 10 years, and 67% survive longer than 15 years.
Because prostate cancer is a slow-growing disease, many men with this disease will die from other causes before they die from prostate cancer. Evidence also indicates that many patients detect their prostate cancer at an earlier stage because of annual screening.
Reviewed by the doctors at The Cleveland Clinic Urological
Institute.
Indication
Uroxatral® (alfuzosin HCl 10 mg extended-release tablets) is an alpha1-blocker for the treatment of the signs and symptoms of BPH.
Important Safety Information
Do not take UROXATRAL if you have liver problems or if you are taking antifungal drugs like ketoconazole or itraconazole, or HIV drugs like ritonavir.
UROXATRAL can cause a sudden drop in blood pressure, especially when starting treatment. This may lead to fainting, dizziness, and lightheadedness. Do not drive, operate machinery, or do any dangerous activity until you know how UROXATRAL will affect you. This is especially important if you already have a problem with low blood pressure or take medicines to treat high blood pressure. There may be an increased risk of low blood pressure and fainting when taking UROXATRAL in combination with blood pressure medication or nitrates, or erectile dysfunction medication.
If considering cataract surgery (clouding of the eyes), tell your eye surgeon that you are currently taking UROXATRAL or have previously been treated with an alpha-blocker.
Before taking UROXATRAL, tell your doctor if you have kidney problems.
Also, tell your doctor if you or any family member(s) have or take medications for a rare heart condition known as congenital prolongation of the QT interval.
BPH and prostate cancer can cause the same symptoms. However, UROXATRAL is not a treatment for prostate cancer.
The most common side effects with UROXATRAL are dizziness, upper respiratory tract infection, headache, and tiredness.
Please see UROXATRAL full prescribing information.
Symptoms of an Enlarged Prostate
Sheldon Marks, MD, explains nearly everything you need to know about an enlarged prostate but were afraid to ask.
