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Genetics of Prostate Cancer (PDQ®): Genetics - Health Professional Information [NCI] - Changes to This Summary (09 / 30 / 2014)

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

Identifying Genes and Inherited Variants Associated With Prostate Cancer Risk

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Added text to state that additional insights are emerging regarding the potential interaction between single nucleotide polymorphisms (SNPs) identified from genome-wide association studies (GWAS) and prostate cancer susceptibility gene regulation. Also added text about a study that found that the T allele of a SNP at 6q22 enhanced binding of HOXB13, leading to allele-specific upregulation of RFX6, which correlates with prostate cancer progression and severity (cited Huang et al. as reference 218).

The Inherited Variants Associated With Prostate Cancer Aggressiveness subsection was comprehensively reviewed and extensively revised.

This summary is written and maintained by the PDQ Cancer Genetics Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Public Information from the National Cancer Institute

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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