Added text to state that additional insights are emerging regarding the potential interaction between single nucleotide polymorphisms (SNPs) identified from genome-wide association studies (GWAS) and prostate cancer susceptibility gene regulation. Also added text about a study that found that the T allele of a SNP at 6q22 enhanced binding of HOXB13, leading to allele-specific upregulation of RFX6, which correlates with prostate cancer progression and severity (cited Huang et al. as reference 218).
The Inherited Variants Associated With Prostate Cancer Aggressiveness subsection was comprehensively reviewed and extensively revised.
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