Prostate Cancer Health Center
Prostate Cancer,Advanced or Metastatic - Symptoms
Prostate cancer may not cause noticeable symptoms. Possible symptoms of locally advanced prostate cancer are:
- Having difficulty starting your urine stream. This is called hesitancy.
- Having a weaker-than-normal urine stream.
- Not being able to urinate at all.
- Having to urinate often.
- Feeling that your bladder is not emptying completely when you urinate.
- Having to get up at night to urinate. This is called nocturia.
- Having pain or a burning feeling when you urinate. This is called dysuria.
- Having blood in your urine. This is called hematuria.
- Having a deep pain in your lower back, abdomen, hip, or pelvis.
- Having blood in your semen. This is called hematospermia or hemospermia.
These symptoms also may be caused by:
- Benign prostatic hyperplasia (BPH), which is an enlarged prostate. This is very common in older men. The prostate usually grows larger with age. When it gets large enough, it can press against the urethra and cause urination problems.
- Prostatitis, an infection in the prostate.
- Urinary tract infection, an infection in any of the organs and tubes that process and carry urine out of the body.
Symptoms that may indicate the cancer has spread to other parts of the body, or metastasized, include:
- Weight loss.
- Bone pain.
- Swelling in the legs and feet.
WebMD Medical Reference from Healthwise
Prostate Cancer,Advanced or Metastatic Topics
Indication
Uroxatral® (alfuzosin HCl 10 mg extended-release tablets) is an alpha1-blocker for the treatment of the signs and symptoms of BPH.
Important Safety Information
Do not take UROXATRAL if you have liver problems or if you are taking antifungal drugs like ketoconazole or itraconazole, or HIV drugs like ritonavir.
UROXATRAL can cause a sudden drop in blood pressure, especially when starting treatment. This may lead to fainting, dizziness, and lightheadedness. Do not drive, operate machinery, or do any dangerous activity until you know how UROXATRAL will affect you. This is especially important if you already have a problem with low blood pressure or take medicines to treat high blood pressure. There may be an increased risk of low blood pressure and fainting when taking UROXATRAL in combination with blood pressure medication or nitrates, or erectile dysfunction medication.
If considering cataract surgery (clouding of the eyes), tell your eye surgeon that you are currently taking UROXATRAL or have previously been treated with an alpha-blocker.
Before taking UROXATRAL, tell your doctor if you have kidney problems.
Also, tell your doctor if you or any family member(s) have or take medications for a rare heart condition known as congenital prolongation of the QT interval.
BPH and prostate cancer can cause the same symptoms. However, UROXATRAL is not a treatment for prostate cancer.
The most common side effects with UROXATRAL are dizziness, upper respiratory tract infection, headache, and tiredness.
Please see UROXATRAL full prescribing information.

