Radical prostatectomy involves surgically removing the entire prostate gland and some surrounding tissue. This treatment is recommended to treat early stages of the disease. Discover how common this procedure is, the complications involved with this surgery, and more.
Radical Prostatectomy for Prostate Cancer
Soy foods (e.g., soy milk, miso, tofu, and soy flour) contain phytochemicals that may have health benefits and, among these, soy isoflavones have been the focus of most of the research.
Soy isoflavones are phytoestrogens. The major isoflavones in soybeans are genistein (the most abundant), daidzein, and glycitein.
Genistein affects components of multiple growth and proliferation -related pathways in prostate cancer cells, including the COX-2 /prostaglandin, epidermal growth factor (EGF), and insulin-like growth factor (IGF) pathways.
Some preclinical studies have indicated that the combined effect of multiple isoflavones may be greater than that of a single isoflavone.
Some animal studies have demonstrated prostate cancer prevention effects with soy and genistein; however, other animal studies have yielded conflicting results regarding beneficial effects of genistein on prostate cancer metastasis.
Epidemiologic studies have generally found high consumption of nonfermented soy foods to be associated with a decreased risk of prostate cancer.
Limited human prevention studies have been conducted, and, so far, they have not yielded consistent or definitive findings.
Treatment trials of various doses and preparations of soy isoflavones in men with prostate cancer have yielded varying results but have generally failed to demonstrate significant effects on prostate-specific antigen (PSA) levels.
A few clinical trials of soy protein or whole soy products have provided preliminary evidence of the ability of these products to lower PSA levels in men with prostate cancer.
Soy products are generally well tolerated in patients with prostate cancer. In clinical trials, the most commonly reported side effects were mild gastrointestinal symptoms.
General Information & History
Although records of soy use in China date back to the eleventh century BC, it was not until the 18th century that the plant reached Europe and the United States. The soybean is an incredibly versatile plant: it can be processed into a variety of products including soy milk, miso, tofu, soy flour, and soy oil.
Soy foods contain a number of phytochemicals that may have health benefits but isoflavones have garnered the most attention. Among the isoflavones found in soybeans, genistein is the most abundant and may have the most biological activity. Other isoflavones found in soy include daidzein and glycitein. Isoflavones help soybeans survive in times of stress and have antioxidant, antimicrobial, and antifungal properties.