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Stage I Prostate Cancer Treatment

    Overview

    Stage I prostate cancer is defined by the American Joint Committee on Cancer's TNM classification system:[1]

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    Prostate Cancer: The Basics

    The prostate is a muscular, walnut-sized gland that surrounds part of the urethra, the tube that transports urine and sperm out of the body. A gland is a group of cells that secretes chemicals that act on or control the activity of other cells or organs. The prostate is part of the male reproductive system. Its main job is to make seminal fluid, the milky substance that transports sperm. Sperm is produced in the testicles, which also make the male hormone testosterone. Testosterone stimulates the...

    Read the Prostate Cancer: The Basics article > >

    • T1a–c, N0, M0, prostate-specific antigen (PSA) <10 ng/ml, Gleason ≤6.
    • T2a, N0, M0, PSA <10 ng/ml, Gleason ≤6.
    • T1–2a, N0, M0, PSA X, Gleason X.

    The frequency of clinically silent, nonmetastatic prostate cancer that can be found at autopsy greatly increases with age and may be as high as 50% to 60% in men aged 90 years and older. Undoubtedly, the incidental discovery of these occult cancers at prostatic surgery performed for other reasons accounts for the similar survival of men with stage I prostate cancer, compared with the normal male population, adjusted for age.

    Many stage I cancers are well differentiated and only focally involve the gland (T1a, N0, M0); most require no treatment other than careful follow-up.[2]

    In younger patients (aged 50–60 years) whose expected survival is long, treatment should be considered.[3] Radical prostatectomy, external-beam radiation therapy (EBRT), interstitial implantation of radioisotopes, and watchful waiting and active surveillance yield apparently similar survival rates in noncontrolled, selected series. The decision to treat should be made in the context of the patient's age, associated medical illnesses, and personal desires.[3]

    Standard Treatment Options for Stage I Prostate Cancer

    Standard treatment options for stage I prostate cancer include the following:

    1. Watchful waiting or active surveillance.
    2. Radical prostatectomy.
    3. External-beam radiation therapy (EBRT).
    4. Interstitial implantation of radioisotopes.

    Watchful waiting or active surveillance

    Asymptomatic patients of advanced age or with concomitant illness may warrant consideration of careful observation without immediate active treatment.[4,5,6] Watch and wait, observation, expectant management, and active surveillance are terms indicating a strategy that does not employ immediate therapy with curative intent. (Refer to the Watchful Waiting or Active Surveillance section in the Treatment Option Overview for Prostate Cancer section of this summary for more information.)

    Evidence (observation with delayed hormonal therapy):

    1. In a retrospective pooled analysis, 828 men with clinically localized prostate cancer were managed by initial conservative therapy with subsequent hormonal therapy given at the time of symptomatic disease progression.
      • This study showed that the patients with grade 1 or grade 2 tumors experienced a disease-specific survival of 87% at 10 years and that their overall survival (OS) closely approximated the expected survival among men of similar ages in the general population.[4]
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