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Prostate Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage Information for Prostate Cancer

Table 3. Definitions of TNM Stage III

StageTNMDescription
T = Primary tumor; N = Regional lymph nodes; M = Distant metastasis; G = Histopathologic grade.
Reprinted with permission fromAJCC: Prostate. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 457-68.
The explanations for superscripts a and c are at the end ofTable 4.
IIIT3, N0, M0, any GT3 = Tumor extends through the prostate capsule.c
N0 = No regional lymph node metastasis.
M0 = No distant metastasis.a
GX = Grade cannot be assessed.
G1 = Well differentiated (slight anaplasia) (Gleason score of 2–4).
G2 = Moderately differentiated (moderate anaplasia) (Gleason score of 5–6).
G3–4 = Poorly differentiated or undifferentiated (marked anaplasia) (Gleason score of 7–10).

Table 4. Definitions of TNM Stage IV

StageTNMDescription
T = Primary tumor; N = Regional lymph nodes; M = Distant metastasis; G = Histopathologic grade; p = Pathologic.
Reprinted with permission fromAJCC: Prostate. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 457-68.
a When more than one site of metastasis is present, the most advanced category (pM1c) is used.
b Tumor found in one or both lobes by needle biopsy, but not palpable or reliably visible by imaging, is classified as T1c.
c Invasion into the prostatic apex or into (but not beyond) the prostatic capsule is classified not as T3 but as T2.
IVT4, N0, M0, any GT4 = Tumor is fixed or invades adjacent structures other than seminal vesicles such as external sphincter, rectum, bladder, levator muscles, and/or pelvic wall.
N0 = No regional lymph node metastasis.
M0 = No distant metastasis.a
GX = Grade cannot be assessed.
G1 = Well differentiated (slight anaplasia) (Gleason score of 2–4).
G2 = Moderately differentiated (moderate anaplasia) (Gleason score of 5–6).
G3–4 = Poorly differentiated or undifferentiated (marked anaplasia) (Gleason score of 7–10).
Any T, N1, M0, any GTX = Primary tumor cannot be assessed.
T0 = No evidence of primary tumor.
T1 = Clinically inapparent tumor not palpable or visible by imaging.
T1a = Tumor incidental histologic finding in ≤5% of tissue resected.
T1b = Tumor incidental histologic finding in >5% of tissue resected.
T1c = Tumor identified by needle biopsy (e.g., because of elevated PSA).
T2 = Tumor confined within prostate.b
T2a = Tumor involves ≤50% of one lobe.
T2b = Tumor involves >50% of one lobe but not both lobes.
T2c = Tumor involves both lobes.
T3 = Tumor extends through the prostate capsule.c
T3a = Extracapsular extension (unilateral or bilateral).
T3b = Tumor invades seminal vesicle(s).
T4 = Tumor is fixed or invades adjacent structures other than seminal vesicles such as the bladder, external sphincter, rectum, levator muscles, and/or pelvic wall.
N1 = Metastasis in regional lymph node(s).
M0 = No distant metastasis.a
GX = Grade cannot be assessed.
G1 = Well differentiated (slight anaplasia) (Gleason score of 2–4).
G2 = Moderately differentiated (moderate anaplasia) (Gleason score of 5–6).
G3–4 = Poorly differentiated or undifferentiated (marked anaplasia) (Gleason score of 7–10).
Any T, any N, M1, any GTX = Primary tumor cannot be assessed.
T0 = No evidence of primary tumor.
T1 = Clinically inapparent tumor not palpable or visible by imaging.
T1a = Tumor incidental histologic finding in ≤5% of tissue resected.
T1b = Tumor incidental histologic finding in >5% of tissue resected.
T1c = Tumor identified by needle biopsy (e.g., because of elevated PSA).
T2 = Tumor confined within prostate.c
T2a = Tumor involves ≤50% of one lobe.
T2b = Tumor involves >50% of one lobe but not both lobes.
T2c = Tumor involves both lobes.
T3 = Tumor extends through the prostate capsule.c
T3a = Extracapsular extension (unilateral or bilateral).
T3b = Tumor invades seminal vesicle(s).
T4 = Tumor is fixed or invades adjacent structures other than seminal vesicles such as the bladder, external sphincter, rectum, levator muscles, and/or pelvic wall.
NX = Regional lymph nodes were not assessed.
pNX = Regional nodes not sampled.
N0 = No regional lymph node metastasis.
pN0 = No positive regional nodes.
N1 = Metastasis in regional lymph node(s).
pN1 = Metastases in regional node(s).
M1 = Distant metastasis.a
M1a = Nonregional lymph node(s).
M1b = Bone(s).
M1c = Other site(s) with or without bone disease.
GX = Grade cannot be assessed.
G1 = Well differentiated (slight anaplasia) (Gleason score of 2–4).
G2 = Moderately differentiated (moderate anaplasia) (Gleason score of 5–6).
G3–4 = Poorly differentiated or undifferentiated (marked anaplasia) (Gleason score of 7–10).
1|2|3|4|5|6

WebMD Public Information from the National Cancer Institute

Last Updated: February 25, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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